basic FUNCTION
| deactivating the inhibitor of kappa light polypeptide enhancer in B cells (NFKB) |
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phosphorylating sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor |
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is an essential regulator of NFKB-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure |
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involved in the negative regulation of macrophage activation and inflammation |
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promoting recombinase activator genes (RAG) transcription |
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playing a major role in regulating the biological effects of estrogen via its promoter association |
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controlling skeletal and craniofacial morphogenesis by repressing expression of fibroblast growth factor (FGF) family members, such as FGF8 |
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having an important role in the activation of nuclear factor-kB (NF-kB), a key regulator of normal and tumor cell proliferation, apoptosis, and response to chemotherapy |
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playing a potential role in bile duct disease |
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functioning as a molecular switch that controls epidermal differentiation |
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functions as a tumor suppressor in human squamous cell carcinomas (SCCs) of skin, lungs, and head and neck |
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CHUK and alkaline phosphatase are negative regulators of IRF5 activity in MYD88 pathway and have role in the control of the inflammatory response by attenuation of IRF5 activity |
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plays a critical role in mediation of the UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression |
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role of IKKalpha in regulating cell cycle progression during the cellular UVB response |
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key mediator of the inflammation and metastasis in prostate cancer, playing a major role in prostate cancer invasion and metastasis, but not in cell proliferation |
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RIPK4 and CHUK might function via closely related pathways to promote keratinocyte differentiation and epithelial growth 8) |
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IKBKG together with the catalytic subunits CHUK and IKBKB, plays an essential role in the formation of the IKK complex and in the activation of the canonical NFKB pathway |
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