Symbol
| CHUK
| contributors: mct - updated : 09-11-2015
|
HGNC name
| conserved helix-loop-helix ubiquitous kinase
|
HGNC id
| 1974
|
corresponding disease(s)
|
COCS
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
| deletion
|  
|  
|
protecting against neurodegeneration in cerebral ischemia | constitutional
|  
|  
|  
| loss of function
|
in exon 15 | tumoral
|  
|  
| --low
|  
|
provides a selective growth advantage that cooperates with Ras activity to promote skin carcinogenesis | |
Susceptibility
|
to squamous cell carcinomas |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | | | |
targeting CHUK might be promising for the prevention of UVB-induced cell damage and tumorigenic effects | miscelleaneous | | | |
CHUK inhibitor for stroke therapy | cancer | | | |
loss of TP53-mediated control over ETS1-dependent transactivation of CHUK may represent a novel pathway for the constitutive activation of NF-kB-mediated gene expression and therapy resistance in cancer | cancer | reproductive | prostate | |
silencing of CHUK with siRNA may therefore provide a promising therapeutic strategy for prostate cancer patients | cancer | digestive | liver | |
IKK-targeted gene therapy can be used in the treatment of hepatocellular carcinoma, a cancer that is notoriously resistant to radiation and chemotherapy |
| | | |
| Ikkalpha(-/-) mice present with a hyperproliferative and undifferentiated epidermis characterized by complete absence of a granular layer and stratum corneum (Descarques, 2008) |