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FLASH GENE
Symbol CHUK contributors: mct - updated : 09-11-2015
HGNC name conserved helix-loop-helix ubiquitous kinase
HGNC id 1974
ASSOCIATED DISORDERS
corresponding disease(s) COCS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
protecting against neurodegeneration in cerebral ischemia
constitutional       loss of function
in exon 15
tumoral     --low  
provides a selective growth advantage that cooperates with Ras activity to promote skin carcinogenesis
Susceptibility to squamous cell carcinomas
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancer  
targeting CHUK might be promising for the prevention of UVB-induced cell damage and tumorigenic effects
miscelleaneous  
CHUK inhibitor for stroke therapy
cancer  
loss of TP53-mediated control over ETS1-dependent transactivation of CHUK may represent a novel pathway for the constitutive activation of NF-kB-mediated gene expression and therapy resistance in cancer
cancerreproductiveprostate
silencing of CHUK with siRNA may therefore provide a promising therapeutic strategy for prostate cancer patients
cancerdigestiveliver
IKK-targeted gene therapy can be used in the treatment of hepatocellular carcinoma, a cancer that is notoriously resistant to radiation and chemotherapy
ANIMAL & CELL MODELS
  • Ikkalpha(-/-) mice present with a hyperproliferative and undifferentiated epidermis characterized by complete absence of a granular layer and stratum corneum (Descarques, 2008)