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FLASH GENE
Symbol CHST3 contributors: mct - updated : 05-03-2007
HGNC name carbohydrate (chondroitin 6) sulfotransferase 3
HGNC id 1971
Corresponding disease
LRS2 Larsen syndrome 2
SEDO spondyloepiphyseal dysplasia, Omani type
Location 10q22.1      Physical location : 73.724.119 - 73.773.321
Synonym name
  • chondroitin 6-sulfotransferase C6T1
  • carbohydrate (chondroitin 6/keratan) sulfotransferase 3
  • galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-
  • sulfotransferase 0
    Synonym symbol(s) SEDT, C6ST, C6ST1
    EC.number 2.8.2.17
    DNA
    TYPE functioning gene
    STRUCTURE 49.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EIF4EBP2 10q21-q22 eukaryotic translation initiation factor 4E binding protein 2 NODAL 10q21.1-q22.2 nodal homolog (mouse) KIAA1274 10q22.1 nodal homolog (mouse) PRF1 10q22.2 perforin 1 (pore forming protein) ADAMTS14 10q21.3 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 C10orf27 10q22.2 chromosome 10 open reading frame 27 LOC338611 10q22.2 similar to 40S ribosomal protein S26 SGPL1 10q22 sphingosine-1-phosphate lyase 1 PCBD 10q22 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) UNC5B 10q22.2 unc-5 homolog B (C. elegans) SLC29A3 10q22.2 solute carrier family 29 (nucleoside transporters), member 3 CDH23 10q22.3 cadherin related 23 PSAP 10q22.1 prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) CHST3 10q22.1 carbohydrate (chondroitin 6) sulfotransferase 3 SPOCK2 10pter-q25.3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 CGI-18 10pter-q25.3 CGI-18 protein LOC119504 10q22.2 hypothetical protein LOC119504 RTP801 DNAJB12 10q22.3 DnaJ (Hsp40) homolog, subfamily B, member 12 CBARA1 10q22.3 calcium binding atopy-related autoantigen 1 C10orf42 10q22.2 chromosome 10 open reading frame 42 FLJ39116 10q22.2-q22.3 oncoprotein induced transcript 3 PLA2G13 10q22.3 phospholipase A2, group XIII LOC148854 10q22.3 similar to 60S ribosomal protein L17 (L23) P4HA1 10q22.3 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I NUDT13 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 HSGT1 10q22.3 nudix (nucleoside diphosphate linked moiety X)-type motif 13 DNAJC9 10q22.3 DnaJ (Hsp40) homolog, subfamily C, member 9 MRPS16 10q22.1 mitochondrial ribosomal protein S16 LOC118491 10q22.3 tetratricopeptide repeat-containing protein ANXA7 10q21.1-q21.2 annexin A7
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas    
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transmembrane domain
  • a sulfotransferase domain
  • HOMOLOGY
    interspecies homolog to murine Chst3
    homolog to Drosophila CG1332
    homolog to C.elegans T01H10.8
    Homologene
    FAMILY
  • sulfotransferase family
  • Gal/GlcNAc/GalNAc subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text Golgi membrane-bound
    basic FUNCTION catalyzing the sulfation of keratan sulfate
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    mucopolysaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SEDO , LRS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS