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FLASH GENE
Symbol CHST3 contributors: mct - updated : 05-03-2007
HGNC name carbohydrate (chondroitin 6) sulfotransferase 3
HGNC id 1971
Corresponding disease
LRS2 Larsen syndrome 2
SEDO spondyloepiphyseal dysplasia, Omani type
Location 10q22.1      Physical location : 73.724.119 - 73.773.321
Synonym name
  • chondroitin 6-sulfotransferase C6T1
  • carbohydrate (chondroitin 6/keratan) sulfotransferase 3
  • galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-
  • sulfotransferase 0
    Synonym symbol(s) SEDT, C6ST, C6ST1
    EC.number 2.8.2.17
    DNA
    TYPE functioning gene
    STRUCTURE 49.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrinepancreas    
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transmembrane domain
  • a sulfotransferase domain
  • HOMOLOGY
    interspecies homolog to murine Chst3
    homolog to Drosophila CG1332
    homolog to C.elegans T01H10.8
    Homologene
    FAMILY
  • sulfotransferase family
  • Gal/GlcNAc/GalNAc subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text Golgi membrane-bound
    basic FUNCTION catalyzing the sulfation of keratan sulfate
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    mucopolysaccharides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SEDO , LRS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS