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FLASH GENE
Symbol CHST10 contributors: mct - updated : 01-12-2015
HGNC name carbohydrate sulfotransferase 10
HGNC id 19650
Location 2p11.2      Physical location : 101.008.322 - 101.034.091
Genatlas name human natural killer-1 sulfotransferase
Synonym name
  • HNK1-sulfotransferase
  • Synonym symbol(s) HNK1ST, HNK-1ST
    DNA
    TYPE functioning gene
    STRUCTURE 25.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TSGA10 2q11.2 testis specific, 10 MGC29762 LIPT1 2q11.2 testis specific, 10 LOC129531 2q11.2 hypothetical protein BC018453 MRPL30 2q11.2 mitochondrial ribosomal protein L30 LYG2 2q11.2 lysozyme-like LOC129530 2q11.2 hypothetical protein LOC129530 APACD 2q11.2 ATP binding protein associated with cell differentiation IF2 2p11.1-q11.1 ATP binding protein associated with cell differentiation REV1L 2q11.1-q11.2 REV1-like (yeast) LAF4 2q11.2-q12 lymphoid nuclear protein related to AF4 LOC389009 2 LOC389009 FLJ45273 2q12.1 FLJ45273 protein HCP7 2q11.2 cytochrome c, somatic pseudogene CHST10 2p11.2 carbohydrate sulfotransferase 10 LOC129522 2q12.1 similar to RalA binding protein 1 (RalBP1) (Ral interacting protein 1) (76-kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) LOC129521 2q12.1 similar to hypothetical protein VIAF1 2q12.1 IAP-associated factor VIAF1 LOC150580 2q12.1 similar to hypothetical protein FLJ39426 LOC389010 2 LOC389010 NPAS2 2p11.2-q12 neuronal PAS domain protein 2 RPL31 2q12.1 ribosomal protein L31 TBC1D8 2q12.1 TBC1 domain family, member 8 (with GRAM domain) C40 2q12.1 hypothetical protein C40 LOC389011 2 LOC389011 LOC391410 2 similar to peptidyl-Pro cis trans isomerase RNF149 2q12.1 ring finger protein 149 CREG2 2q11.2 ring finger protein 149 LOC389012 2 similar to hypothetical protein MGC33442 LOC389013 2 LOC389013 LOC389014 2 LOC389014 LOC391411 2 similar to ribosomal protein S6 LOC391412 2 similar to Lysosomal Pro-X carboxypeptidase precursor (Prolylcarboxypeptidase) (PRCP) (Proline carboxypeptidase) (Angiotensinase C) (Lysosomal carboxypeptidase C) MAP4K4 2q11.2 mitogen-activated protein kinase kinase kinase kinase 4
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Nervousbrain   predominantly
    Reproductivefemale systemovary   
     male systemtestis  highly
     male systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic N terminal tail
  • hydrophobic transmembrane segment (TM1)
  • an extracellular catalytic domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG18012
    homolog to C.elegans T26A5.4
    Homologene
    FAMILY sulfotransferase 2 family
    CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • involved in the biosynthesis of the B3GAT1 carbohydrate epitope on both glycoprotein and glycolipids in the nervous system
  • may be indirectly involved in synapse plasticity of the hippocampus, via its role in B3GAT1 biosynthesis
  • mutual catalytic domains of B3GAT1 or B3GAT2 and CHST10 are important and sufficient for formation of an enzyme complex
  • CHST10 functions as a suppressor of invasiveness, but not proliferation, in melanomas cells
  • its sulfotransferase activity is essential for the modulation of DAG1
  • novel role for CHST10 as a regulator of the functional glycans on DAG1 other than B3GAT1 biosynthesis
  • novel role for CHST10 as a tumor suppressor controlling the functional glycans on DAG1 and the importance of sulfate transfer in the glycosylation of DAG1
  • novel tumor-suppressive role for CHST10, which acts as a functional regulator of DAG1 via sulfate transfer
  • adds sulfate to glucuronic acid to form a carbohydrate antigen, B3GAT1, in glycoproteins and glycolipids
  • given that CHST10 transfers sulfates to several steroid hormones, it likely functions in widespread regulation of steroid hormones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a sulfotransferase that forms B3GAT1 glycan on neural cell adhesion proteins and glycolipids, and B3GAT1 is thought to modulate cell adhesion and possibly metastasis
  • CHST10 is involved in 3-O-sulfation of the terminal glucuronic acid of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of chondroitin sulfate chain biosynthesis on thrombomodulin
  • CHST10 suppressed the glycosylation and reduced the ligand binding activity of DAG1
  • sulfate transfer induced by CHST10 plays a regulatory role in the formation of functional glycans DAG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS