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FLASH GENE
Symbol CHST10 contributors: mct - updated : 01-12-2015
HGNC name carbohydrate sulfotransferase 10
HGNC id 19650
Location 2p11.2      Physical location : 101.008.322 - 101.034.091
Genatlas name human natural killer-1 sulfotransferase
Synonym name
  • HNK1-sulfotransferase
    • Synonym symbol(s) HNK1ST, HNK-1ST
    DNA
    TYPE functioning gene
    STRUCTURE 25.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Nervousbrain   predominantly
    Reproductivefemale systemovary   
     male systemtestis  highly
     male systemprostate   
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic N terminal tail
  • hydrophobic transmembrane segment (TM1)
  • an extracellular catalytic domain
    • HOMOLOGY
    interspecies homolog to Drosophila CG18012
    homolog to C.elegans T26A5.4
    Homologene
    FAMILY sulfotransferase 2 family
    CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • involved in the biosynthesis of the B3GAT1 carbohydrate epitope on both glycoprotein and glycolipids in the nervous system
  • may be indirectly involved in synapse plasticity of the hippocampus, via its role in B3GAT1 biosynthesis
  • mutual catalytic domains of B3GAT1 or B3GAT2 and CHST10 are important and sufficient for formation of an enzyme complex
  • CHST10 functions as a suppressor of invasiveness, but not proliferation, in melanomas cells
  • its sulfotransferase activity is essential for the modulation of DAG1
  • novel role for CHST10 as a regulator of the functional glycans on DAG1 other than B3GAT1 biosynthesis
  • novel role for CHST10 as a tumor suppressor controlling the functional glycans on DAG1 and the importance of sulfate transfer in the glycosylation of DAG1
  • novel tumor-suppressive role for CHST10, which acts as a functional regulator of DAG1 via sulfate transfer
  • adds sulfate to glucuronic acid to form a carbohydrate antigen, B3GAT1, in glycoproteins and glycolipids
  • given that CHST10 transfers sulfates to several steroid hormones, it likely functions in widespread regulation of steroid hormones
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a sulfotransferase that forms B3GAT1 glycan on neural cell adhesion proteins and glycolipids, and B3GAT1 is thought to modulate cell adhesion and possibly metastasis
  • CHST10 is involved in 3-O-sulfation of the terminal glucuronic acid of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of chondroitin sulfate chain biosynthesis on thrombomodulin
  • CHST10 suppressed the glycosylation and reduced the ligand binding activity of DAG1
  • sulfate transfer induced by CHST10 plays a regulatory role in the formation of functional glycans DAG1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS