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FLASH GENE
Symbol CHST10 contributors: mct - updated : 01-12-2015
HGNC name carbohydrate sulfotransferase 10
HGNC id 19650
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic N terminal tail
  • hydrophobic transmembrane segment (TM1)
  • an extracellular catalytic domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG18012
    homolog to C.elegans T26A5.4
    Homologene
    FAMILY sulfotransferase 2 family
    CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • involved in the biosynthesis of the B3GAT1 carbohydrate epitope on both glycoprotein and glycolipids in the nervous system
  • may be indirectly involved in synapse plasticity of the hippocampus, via its role in B3GAT1 biosynthesis
  • mutual catalytic domains of B3GAT1 or B3GAT2 and CHST10 are important and sufficient for formation of an enzyme complex
  • CHST10 functions as a suppressor of invasiveness, but not proliferation, in melanomas cells
  • its sulfotransferase activity is essential for the modulation of DAG1
  • novel role for CHST10 as a regulator of the functional glycans on DAG1 other than B3GAT1 biosynthesis
  • novel role for CHST10 as a tumor suppressor controlling the functional glycans on DAG1 and the importance of sulfate transfer in the glycosylation of DAG1
  • novel tumor-suppressive role for CHST10, which acts as a functional regulator of DAG1 via sulfate transfer
  • adds sulfate to glucuronic acid to form a carbohydrate antigen, B3GAT1, in glycoproteins and glycolipids
  • given that CHST10 transfers sulfates to several steroid hormones, it likely functions in widespread regulation of steroid hormones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a sulfotransferase that forms B3GAT1 glycan on neural cell adhesion proteins and glycolipids, and B3GAT1 is thought to modulate cell adhesion and possibly metastasis
  • CHST10 is involved in 3-O-sulfation of the terminal glucuronic acid of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of chondroitin sulfate chain biosynthesis on thrombomodulin
  • CHST10 suppressed the glycosylation and reduced the ligand binding activity of DAG1
  • sulfate transfer induced by CHST10 plays a regulatory role in the formation of functional glycans DAG1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS