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FLASH GENE
Symbol CETP contributors: mct - updated : 08-04-2022
HGNC name cholesteryl ester transfer protein, plasma
HGNC id 1869
Corresponding disease
CETPD cholesteryl ester transfer protein deficiency
Location 16q13      Physical location : 56.995.834 - 57.017.756
Synonym name
  • plasma lipid transfer protein
  • BPI fold containing family F
  • Synonym symbol(s) BPIFF, HDLCQ10
    DNA
    TYPE functioning gene
    STRUCTURE 21.90 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 1717 53.1 493 - 2021 34609279
  • FL-CETP
  • E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner
  • 15 - 1511 - 433 - 2021 34609279
    15 - - - - E9-deleted CETP is not secreted 2020 31988147
  • lacking exon 9
  • E9-deleted CETP, like FL-CETP, alters cellular TG metabolism and storage but in a contrary manner
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveintestinesmall intestine   
     liver    
    Endocrineadrenal gland    
    Nervousbrain    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Connectivecartilage   
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    cell lineage in and throughout differentiation of preadipocyte
    cell lines
    fluid/secretion plasma
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a N terminal half with a LPS binding site
  • a conserved C terminal, required for anchoring lipoprotein particles
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to LBP,low
    Homologene
    FAMILY
  • BPI/LBP family
  • BPI/LBP/Plunc superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol
  • playing a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism
  • role of PLTP and CETP in atherogenesis
  • anti-adipogenic role for CETP
  • CETP might be a limiter of reverse cholesterol transport and HDL maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediates the exchange of cholesteryl ester for triglycerides between HDL and VLDL and LDL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CETPD
    Susceptibility
  • to coronary heart disease and carotid atherosclerosis
  • to exceptional longevity (Barzilai 06)
  • HDL cholesterol level QTL10 (Spirin 07)
  • the development of retinopathy of prematurity (ROP)
  • to age-related macular degeneration
  • to metabolic syndrome
  • to intracerebral hemorrhage (ICH)
  • Variant & Polymorphism SNP , other
  • taq1 B2B2 protective against coronary heart disease (associated with higher levels of plasma HDL-C )
  • functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms is a major determinant of promoter activity and plasma CETP concentration(and HDL levels)
  • association between SNPs and the development of ROP
  • association of variants with age-related macular degeneration (Chen 2010)
  • CETP rs820299 is associated with metabolic syndrome
  • Genetic variants in CETP associated with increased HDL-C raise the risk of ICH
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    CETP inhibitors could have a significant impact in the management of dyslipidemic CHD patients
    ANIMAL & CELL MODELS
    not contributing to the generation of prebeta-HDL in transgenic mice