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FLASH GENE
Symbol CETP contributors: mct - updated : 21-02-2007
HGNC name cholesteryl ester transfer protein, plasma
HGNC id 1869
Corresponding disease
CETPD cholesteryl ester transfer protein deficiency
Location 16q13      Physical location : 56.995.834 - 57.017.756
Synonym name plasma lipid transfer protein
DNA
TYPE functioning gene
STRUCTURE 21.92 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 1717 53.1 493 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveintestinesmall intestine   
 liver    
Endocrineadrenal gland    
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivecartilage   
Epithelialsecretoryglandularendocrine 
Lymphoid    
cell lineage in and throughout differentiation of preadipocyte
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a signal peptide
  • a N terminal half with a LPS binding site
  • a conserved C terminal, required for anchoring lipoprotein particles
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to LBP,low
    Homologene
    FAMILY
  • BPI/LBP family
  • BPI/LBP/Plunc superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol
  • playing a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CETPD
    Susceptibility
  • to coronary heart disease and carotid atherosclerosis
  • to exceptional longevity (Barzilai 06)
  • HDL cholesterol level QTL10 (Spirin 07)
  • the development of retinopathy of prematurity (ROP)
  • to age-related macular degeneration
  • Variant & Polymorphism SNP , other
  • taq1 B2B2 protective against coronary heart disease (associated with higher levels of plasma HDL-C )
  • functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms is a major determinant of promoter activity and plasma CETP concentration(and HDL levels)
  • association between SNPs and the development of ROP
  • association of variants with age-related macular degeneration (Chen 2010)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    not contributing to the generation of prebeta-HDL in transgenic mice