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FLASH GENE
Symbol CETP contributors: mct - updated : 08-04-2022
HGNC name cholesteryl ester transfer protein, plasma
HGNC id 1869
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Digestiveintestinesmall intestine   
 liver    
Endocrineadrenal gland    
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Connectivecartilage   
Epithelialsecretoryglandularendocrine 
Lymphoid    
cell lineage in and throughout differentiation of preadipocyte
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a signal peptide
  • a N terminal half with a LPS binding site
  • a conserved C terminal, required for anchoring lipoprotein particles
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to LBP,low
    Homologene
    FAMILY
  • BPI/LBP family
  • BPI/LBP/Plunc superfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol
  • playing a key role in the determination of high-density lipoprotein (HDL) levels via its action on intravascular HDL metabolism
  • role of PLTP and CETP in atherogenesis
  • anti-adipogenic role for CETP
  • CETP might be a limiter of reverse cholesterol transport and HDL maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediates the exchange of cholesteryl ester for triglycerides between HDL and VLDL and LDL
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CETPD
    Susceptibility
  • to coronary heart disease and carotid atherosclerosis
  • to exceptional longevity (Barzilai 06)
  • HDL cholesterol level QTL10 (Spirin 07)
  • the development of retinopathy of prematurity (ROP)
  • to age-related macular degeneration
  • to metabolic syndrome
  • to intracerebral hemorrhage (ICH)
  • Variant & Polymorphism SNP , other
  • taq1 B2B2 protective against coronary heart disease (associated with higher levels of plasma HDL-C )
  • functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms is a major determinant of promoter activity and plasma CETP concentration(and HDL levels)
  • association between SNPs and the development of ROP
  • association of variants with age-related macular degeneration (Chen 2010)
  • CETP rs820299 is associated with metabolic syndrome
  • Genetic variants in CETP associated with increased HDL-C raise the risk of ICH
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    CETP inhibitors could have a significant impact in the management of dyslipidemic CHD patients
    ANIMAL & CELL MODELS
    not contributing to the generation of prebeta-HDL in transgenic mice