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FLASH GENE
Symbol CEP55 contributors: mct/npt/pgu - updated : 18-09-2013
HGNC name centrosomal protein 55kDa
HGNC id 1161
Location 10q23.33      Physical location : 95.256.368 - 95.288.847
Synonym name
  • chromosome 10 open reading frame 3
  • up-regulated in colon cancer 6
  • cancer/testis antigen 111
  • Synonym symbol(s) FLJ10540, C10orf3, URCC6, CT111
    DNA
    TYPE functioning gene
    STRUCTURE 32.48 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2656 54 464 - 2006 16406728
    9 - 2534 - 464 - 2006 16406728
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines various cancer
    fluid/secretion
    at STAGE
    physiological period fetal
    Text heart and spleen
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three central coiled-coil domains responsible for protein-protein interactions
  • a domain known as AAA (ATPases associated with a variety of cellular activities)
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • localizes to the mitotic spindle during prometaphase and metaphase and to the spindle midzone and the midbody during anaphase and cytokinesis
  • localized to the centrosome in interphase cells
  • basic FUNCTION
  • playing a role in cytokinesis as its depletion by siRNA results in failure of this process
  • contributing to spindle pole organization and playing a role in cell cycle progression as well as completing cytokinesis
  • involved in in centrosome-dependent cellular functions, such as centrosome duplication and/or cell cycle progression, or in the regulation of cytokinesis
  • regulator required for the completion of cytokinesis
  • microtubule-associated protein that efficiently bundles microtubules
  • plays an essential role in the G2/M phase of the cell cycle and display dynamic cellular distribution patterns during cell-cycle progression
  • mitotic phosphoprotein that plays an important role in cytokinesis, the final stage of cell division during which physical separation of the two daughter cells is accomplished
  • regulator required for the completion of cell abscission
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ESCRT-III (CHMP) proteins pathhway
    a component
  • capable of homodimerization
  • complexing with PI3K
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EGFP in all stages of mitosis
  • interacting with TSG101 (downregulated TSG101 in a post-transcriptional manner)
  • forms a complex with PI3K and can activate PI3K activity
  • associates with the KIF23-RACGAP1 centralspindlin complex
  • linking RACGAP1 through a cellular mechanism which, in turn, controls the midbody structure and membrane fusion at the terminal stage of cytokinesis
  • PLK1 activity negatively regulates CEP55 to ensure orderly abscission factor recruitment and ensures that this occurs only once cell contraction has completed
  • TP53-PLK1-CEP55 axis in which TP53 negatively regulates expression of CEP55, through PLK1 which, in turn, is a positive regulator of CEP55 protein stability
  • associates with and is phosphorylated by PLK1 during mitosis (tight regulation of CEP55 protein levels by TP53 is mediated by PLK1 phosphorylation)
  • BRCA2 localization to the midbody by FLNA regulates CEP55 signaling and completion of cytokinesis
  • cell & other
  • directly interacting with centrosome components rather than with microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers (CRC) as well as in tumors arising in the stomach, lung, pancreas, and breast
    tumoral     --over  
    in hepatocellular carcinoma
    tumoral     --over  
    overexpressed inoral squamous cell carcinomas, thus stimulating cell migration and invasion through increased FOXM1 and MMP2 expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • potential new therapeutic target for hepatocellular carcinoma treatment and may contribute to the development of new therapeutic strategies that are able to block the PI3K/AKT pathway in cancer cells
  • novel therapeutic target for oral squamous cell carcinomas (OCSCC) because suppression of CEP55 could cause significant inhibition on cell migratory and invasive ability in oral cancer cells
  • ANIMAL & CELL MODELS