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FLASH GENE
Symbol CEP55 contributors: mct/npt/pgu - updated : 18-09-2017
HGNC name centrosomal protein 55kDa
HGNC id 1161
DNA
TYPE functioning gene
STRUCTURE 32.48 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2656 54 464 - 2006 16406728
9 - 2534 - 464 - 2006 16406728
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines various cancer
fluid/secretion
at STAGE
physiological period fetal
Text heart and spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three central coiled-coil domains responsible for protein-protein interactions
  • a domain known as AAA (ATPases associated with a variety of cellular activities)
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • localizes to the mitotic spindle during prometaphase and metaphase and to the spindle midzone and the midbody during anaphase and cytokinesis
  • localized to the centrosome in interphase cells
  • basic FUNCTION
  • playing a role in cytokinesis as its depletion by siRNA results in failure of this process
  • contributing to spindle pole organization and playing a role in cell cycle progression as well as completing cytokinesis
  • involved in in centrosome-dependent cellular functions, such as centrosome duplication and/or cell cycle progression, or in the regulation of cytokinesis
  • regulator required for the completion of cytokinesis
  • microtubule-associated protein that efficiently bundles microtubules
  • plays an essential role in the G2/M phase of the cell cycle and display dynamic cellular distribution patterns during cell-cycle progression
  • mitotic phosphoprotein that plays an important role in cytokinesis, the final stage of cell division during which physical separation of the two daughter cells is accomplished
  • regulator required for the completion of cell abscission
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ESCRT-III (CHMP) proteins pathhway
    a component
  • capable of homodimerization
  • complexing with PI3K
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EGFP in all stages of mitosis
  • interacting with TSG101 (downregulated TSG101 in a post-transcriptional manner)
  • forms a complex with PI3K and can activate PI3K activity
  • associates with the KIF23-RACGAP1 centralspindlin complex
  • linking RACGAP1 through a cellular mechanism which, in turn, controls the midbody structure and membrane fusion at the terminal stage of cytokinesis
  • PLK1 activity negatively regulates CEP55 to ensure orderly abscission factor recruitment and ensures that this occurs only once cell contraction has completed
  • TP53-PLK1-CEP55 axis in which TP53 negatively regulates expression of CEP55, through PLK1 which, in turn, is a positive regulator of CEP55 protein stability
  • associates with and is phosphorylated by PLK1 during mitosis (tight regulation of CEP55 protein levels by TP53 is mediated by PLK1 phosphorylation)
  • BRCA2 localization to the midbody by FLNA regulates CEP55 signaling and completion of cytokinesis
  • TEX14 competitively binds to CEP55-EABR to prevent the recruitment of PDCD6IP, which is a component of the ESCRT machinery with the AxGPPx3Y motif
  • DDX21 induces CEP55 expression, and MYCN-amplified neuroblastoma cell proliferation and tumorigenesis
  • cell & other
  • directly interacting with centrosome components rather than with microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancers (CRC) as well as in tumors arising in the stomach, lung, pancreas, and breast
    tumoral     --over  
    in hepatocellular carcinoma
    tumoral     --over  
    overexpressed inoral squamous cell carcinomas, thus stimulating cell migration and invasion through increased FOXM1 and MMP2 expression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    DDX21 and CEP55 are valid therapeutic targets for the treatment of MYCN-amplified neuroblastoma
    cancerdigestiveliver
    . potential new therapeutic target for hepatocellular carcinoma treatment and may contribute to the development of new therapeutic strategies that are able to block the PI3K/AKT pathway in cancer cells
    cancerhead and neck 
    novel therapeutic target for oral squamous cell carcinomas (OCSCC) because suppression of CEP55 could cause significant inhibition on cell migratory and invasive ability in oral cancer cells
    ANIMAL & CELL MODELS