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FLASH GENE
Symbol CEBPE contributors: mct/npt - updated : 23-03-2010
HGNC name CCAAT/enhancer binding protein (C/EBP), epsilon
HGNC id 1836
Corresponding disease
SGD neutrophil-specific granule deficiency
Location 14q11.2      Physical location : 23.586.514 - 23.588.474
Synonym name
  • myeloid cell-specific transcription factor
  • CCAAT/enhancer-binding protein epsilon
  • Synonym symbol(s) C/EBP-epsilon, CRP1
    DNA
    TYPE functioning gene
    STRUCTURE 1.96 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - TRP1 - TRL1 - TRP2 - TRA@ - D14S990 - D14S264 - CEBPE /D14S275 - GZMB - CTSG - CMA1 - NP - TGM1 - qter
    Authors Antonson (96),Koike (97)
    Physical map
    ABHD4 14q11.1 abhydrolase domain containing 4 OR6J1P 14p12 olfactory receptor, family 6, subfamily J, member 1 pseudogene RPL26P2 14 ribosomal protein L26 pseudogene 2 LOC390461 14 similar to olfactory receptor C6 OXA1L 14q11.2 oxidase (cytochrome c) assembly 1-like SLC7A7 14q11.2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 MRPL52 14q11.2 mitochondrial ribosomal protein L52 MMP14 14q11.2 matrix metalloproteinase 14 (membrane-inserted) LRP10 14q11.2 low density lipoprotein receptor-related protein 10 FLJ38964 14q11.2 hypothetical protein FLJ38964 RNPC4 14q11.2 RNA-binding region (RNP1, RRM) containing 4 SKB1 14q11.2-q21 SKB1 homolog (S. pombe) C14orf94 14q11.1 chromosome 14 open reading frame 94 JUB 14q11.2 jub, ajuba homolog (Xenopus laevis) C14orf93 14q11.1 chromosome 14 open reading frame 93 PSMB5 14q11.2 proteasome (prosome, macropain) subunit, beta type, 5 LOC122706 14q11.2 similar to RIKEN cDNA 5830406J20 CDH24 14q11.2 cadherin-like 24 ACINUS 14q11.2 apoptotic chromatin condensation inducer in the nucleus C14orf119 14q11.2 chromosome 14 open reading frame 119 CEBPE 14q11.2 CCAAT/enhancer binding protein (C/EBP), epsilon SLC7A8 14q11.2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 RPL39P2 14 ribosomal protein L39 pseudogene 2 HMGN2P 14 high-mobility group nucleosomal binding domain 2 pseudogene KIAA1443 14q11.2 KIAA1443 LOC90673 BCL2L2 14q11.2-q12 BCL2-like 2 PABPN1 14q11.2-q13 poly(A) binding protein, nuclear 1 SLC22A17 14q11.2 solute carrier family 22 (organic cation transporter), member 17 EFS 14q11.2-q12 embryonal Fyn-associated substrate IL17E 14q11.2 interleukin 17E CKLFSF5 14q11.2 chemokine-like factor super family 5 MYH6 14q11.2 myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) MYH7 14q11.2 myosin, heavy polypeptide 7, cardiac muscle, beta C14orf120 14q11.2 chromosome 14 open reading frame 120
    RNA
    TRANSCRIPTS type messenger
    text
  • 4 isoforms (32, 30, 27, and 14 kDa) through differential RNA splicing, and alternative promoters and translational start sites (Bedi 2009)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 1250 30 281 - Chumakov (1997), Bedi (2009)
  • transcriptional activator
  • - splicing - 32 - - Bedi (2009)
  • also called CEBPE32
  • transcriptional activator
  • - splicing - 27 - - Bedi (2009)
  • also called CEBPE27
  • interacts with and represses GATA1 transactivation of eosinophil promoters
  • strongly inhibits eosinophil differentiation and gene expression, including GATA1, promoting granulocyte (neutrophil)-macrophage differentiation
  • - splicing - 14 - - Bedi (2009)
  • also called CEBPE14
  • contains only DNA-binding and -dimerization domains and may function as a dominant-negative regulator
  • strongly inhibits eosinophil development and gene expression, promoting erythroid differentiation, an effect enhanced by erythropoietin
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    cell lineage cells of myeloid lineage, promyelocyte and late-myeloblast-like cell lines
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • basic leucine zipper (bZIP) protein (C/EBP)
  • HOMOLOGY
    interspecies ortholog to rattus crp1
    Homologene
    FAMILY
  • leucine zipper family of transcription factors
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • myelocyte differentiation, premyelocyte to myelocyte transition
  • may be playing an essential role for terminal differentiation and functional maturation of committed granulocyte progenitor cells
  • essential and sufficient for the expression of a particular subset of neutrophil secondary granule genes
  • critical transcription factor in TNFalpha-induced up-regulation of GPX4 expression (Hattori 2007)
  • important regulator of cytokine expression in human neutrophils (Cloutier 2009)
  • required for the terminal differentiation of neutrophils and eosinophils (Bedi 2009)
  • CELLULAR PROCESS nucleotide, transcription
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text myelopoiesis, hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binds DNA as a dimer
  • binding to CCAAT enhancer
  • RNA
    small molecule
    protein
  • expressing the eosinophil granule major basic protein (PRG2) and antagonizing the GATA1/SPI1 synergy
  • interacting with RB1 and E2F1 important in C/EBPepsilon-induced terminal granulocytic differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SGD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS