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FLASH GENE
Symbol CEBPE contributors: mct/npt - updated : 23-03-2010
HGNC name CCAAT/enhancer binding protein (C/EBP), epsilon
HGNC id 1836
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) protein (C/EBP)
  • HOMOLOGY
    interspecies ortholog to rattus crp1
    Homologene
    FAMILY
  • leucine zipper family of transcription factors
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • myelocyte differentiation, premyelocyte to myelocyte transition
  • may be playing an essential role for terminal differentiation and functional maturation of committed granulocyte progenitor cells
  • essential and sufficient for the expression of a particular subset of neutrophil secondary granule genes
  • critical transcription factor in TNFalpha-induced up-regulation of GPX4 expression (Hattori 2007)
  • important regulator of cytokine expression in human neutrophils (Cloutier 2009)
  • required for the terminal differentiation of neutrophils and eosinophils (Bedi 2009)
  • CELLULAR PROCESS nucleotide, transcription
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text myelopoiesis, hematopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binds DNA as a dimer
  • binding to CCAAT enhancer
  • RNA
    small molecule
    protein
  • expressing the eosinophil granule major basic protein (PRG2) and antagonizing the GATA1/SPI1 synergy
  • interacting with RB1 and E2F1 important in C/EBPepsilon-induced terminal granulocytic differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SGD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS