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FLASH GENE
Symbol CDK7 contributors: mct - updated : 18-05-2013
HGNC name cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
HGNC id 1778
Location 5q13.1      Physical location : 68.530.621 - 68.573.256
Synonym name
  • 39kda protein kinase
  • CDK-activating kinase
  • subunit of CAK
  • cell division protein kinase7
  • serine /threonine protein kinase 1
  • serine/threonine protein kinase M015
    • Synonym symbol(s) CAK1, CDKN7, STK1, P39MO15
    EC.number 2.7.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 42.64 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D5S823 - CCNB1 - CDK7 - OCLN - BIRC1 - SMN2 - SERF2 - qter
    Authors Growney (00)
    Text see SMA
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1534 - 346 - 1999 10224071
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    cell lineage
    cell lines breast cancer lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to Xenopus p40-M015
    homolog to murine Cdk7
    ortholog to yeast S.cerevisiae cdc28
    Homologene
    FAMILY
  • cyclin-dependent kinase family
  • ser/thr family of protein kinases
    • CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • CDK-activating kinase 1, linking transcription and the cell-cyle machinery
  • functions as a master cell cycle regulator by phosphorylating cyclin-dependent kinases for cell cycle progression
  • having a putative role in oxidative stress
  • submodule of TFIIH acting as a physiological roadblock to adipogenesis by inhibiting PPARgamma activity
  • ELL and CDK7 play essential yet distinct roles during transcription-coupled repair (TCR)
    • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
    nucleotide, repair
    nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
  • component of the multisubunit complex TFIIH (GTF2H)
  • component of an aternary complex with CCNH and MNAT1 (see symbols)
  • trimeric CDK7/cyclin H/MNAT1 complex functions in cell cycle regulation, as the Cdk-activating kinase, and in transcription, as a module of the general transcription factor TFIIH )
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating POLR2A, when complexed and associated with GTF2H
  • phosphorylating CDK2 and CDC2
  • PRKCI associates with CDK7
  • CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
    • cell & other
    REGULATION
    inhibited by inactivated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to breast cancer
    Variant & Polymorphism other
  • CDK7 TT genotype had increased risk of breast cancer (
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS