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FLASH GENE
Symbol CDIPT contributors: - updated : 24-06-2005
HGNC name CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
HGNC id 1769
Location 16p12.1      Physical location : 29.869.678 - 29.874.578
Synonym name
  • goat polledness and intersexuality gene homolog
  • phosphatidylinositol synthase
  • Synonym symbol(s) PIS, PIS1, MGC1328
    EC.number 2.7.8.11
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D3S1549 - SOX14 - NCK1 - D3S1576 - RBP1 - CP - D3S1316 - D3S3554 - CDIPT - D3S3586 - ATP1B3 - TFDP2 - D3S1309 - qter
    Authors Vaiman (99)
    regionally located in the BEPS region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1820 23.5 213 - Antonsson
    - splicing 1905 - 244 - Antonsson
    including an alternate in frame segment in the coding region
    EXPRESSION
    Type widely
    constitutive ofúLUNG AND BRAIN.
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
     thymus   lowly
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinecolon lowly
     intestinesmall intestine  lowly
     liver   highly
    Endocrinepancreas   lowly
    Nervousbrain   lowly
    Reproductivefemale systemovary  lowly
     male systemtestis  lowly
     male systemprostate  lowly
    Respiratorylung   lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta lowly,kidney and liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to goat polledness and intersexuality gene
    homolog to Drosophila CG9245
    homolog to C.elegans Y46G5A.5
    Homologene
    FAMILY member of the CDP-alcohol phosphatidyl transferase class-I family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    text an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus
    basic FUNCTION having both phosphatidylinositol synthase and phosphatidylinositol :inositol exchange activity
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text phosphatidylinositol transporter
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    phospholipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
    magnesium Mg2+,manganese Mn2+
    protein
    cell & other
    REGULATION
    inhibited by phosphatidylinositol,phosphatidylinositol phosphate and nucleoside di- and tri- phosphates
    calcium Ca2+ and zinc Zn2+
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS