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FLASH GENE

Symbol

CD37

contributors: - updated : 28-12-2006

HGNC name	CD37 antigen
HGNC id	1666

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.3      Physical location : 49.838.676 - 49.843.859
Genatlas name	cell differentiation antigen 37 (gp52-40), 52-40kDa, membrane glycoprotein, identified by monoclonal antibodies G28-1, Y29/55, RFB-7, MB-1, M-B371, M-B372
Synonym name	leukocyte surface antigen CD37
	cell differentiation antigen 37
Synonym symbol(s)	GP52-40, MGC120234, TSPAN26

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 1263 - 281 - Suzuki V2 - - 1229 - 213 - Suzuki

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   tonsils       highly Reproductive male system prostate       Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Lymphoid/Immune lymphocyte

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

tetraspanin (TM4SF) family

CATEGORY

antigen

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
	cell surface glycoprotein complexing with integrins and other transmembrane 4 superfamily proteins and playing a role in T-cell-B-cell interactions
	playing a regulatory role in T cell proliferation by influencing early events of TCR signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS