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FLASH GENE
Symbol CD19 contributors: mct - updated : 25-01-2011
HGNC name CD19 molecule
HGNC id 1633
Corresponding disease
CVID3 common variable immunodeficiency 3
Location 16p11.2      Physical location : 28.943.259 - 28.950.667
Synonym name
  • cell differentiation antigen CD19, B cell surface membrane protein PAX5 (BSAP) dependent, identified by monoclonal antibodies B4, HD37 and others, linked to the integrin associated CD9, CD81, KAI1
  • CD19 antigen
  • B- lymphocyte surface antigen B4
  • differentiation antigen CD19
  • Synonym symbol(s) B4, MGC12802, Leu-12, CVID3
    DNA
    TYPE functioning gene
    STRUCTURE 7.40 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC390687 16 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC388228 16 similar to SH3-binding kinase LOC388229 16 similar to Group X secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GX) (GX sPLA2) (sPLA2-X) EIF3S8 16p11.2 eukaryotic translation initiation factor 3, subunit 8, 110kDa LOC283890 16p12.1 similar to nuclear pore complex interacting protein LOC388230 16 similar to MGC9515 protein LOC388231 16 LOC388231 SULT1A1 16p12.1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 SULT1A2 16p12-p11.2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 LOC112869 16p12.1 hypothetical protein BC011981 P8 16p11.2 p8 protein (candidate of metastasis 1) IL27  interleukin 27 LOC388232 16 similar to apolipoprotein B48 receptor CLN3 16p12.1-p11.2 ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease) LOC388233 16 similar to MGC9515 protein APOB48R 16p11 apolipoprotein B48 receptor LOC388234 16 similar to nuclear pore complex interacting protein LOC390688 16 similar to CDC37-like gene LOC388235 16 LOC388235 LOC388236 16 similar to MGC9515 protein A2LP 16p11 ataxin 2 related protein TUFM 16p11.2 Tu translation elongation factor, mitochondrial SH2B 16p12.1 Tu translation elongation factor, mitochondrial ATP2A1 16p12.1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 FRA 16p12.1 Fos-related antigen CD19 16p11.2 CD19 antigen FLJ14639 16p12.1 hypothetical protein FLJ14639 SPINL 16p12.1 spinster-like LAT 16p11.2 linker for activation of T cells LOC388237 16 similar to nuclear pore complex interacting protein LOC388238 16 similar to RRN3 LOC283892 16p12.1 hypothetical gene supported by NM_017869; AK023827 LOC283895 16p12.1 hypothetical LOC283895 LOC388239 16 similar to nuclear pore complex interacting protein LOC388240 16 similar to MGC9515 protein LOC388241 16 similar to PI-3-kinase-related kinase SMG-1 isoform 2; lambda/iota protein kinase C-interacting protein; phosphatidylinositol 3-kinase-related protein kinase MGC5178 16p12.1 hypothetical protein MGC5178 LOC388242 16 similar to hypothetical protein BC011981 KIAA0220 16p12.1 KIAA0220 protein LAT1-3TM 16p12 LAT1-3TM protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1968 - 557 - 1995 7532151
    15 - 1965 - 556 - 1995 7532151
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
     tonsils   highly
    Nervousbrain    
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • YXXM motif crucial for regulating B-cell development in that mutation of these motifs abrogated their ability to induce BCR-mediated AKT activation as well as to promote B-cell development
  • two immunoglobulin-like C2-type domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cd19
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • may be involved in growth regulation of B-cells
  • assembling with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation
  • essential role for CD19, independent of the costimulatory molecule CD21, in amplifying early B cell activation events in response to membrane-bound ligand stimulation
  • PIK3AP1 and CD19 have complementary roles in BCR-mediated PI3K activation, thereby, at least in part, contributing to B-cell development
  • response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling
  • role for complement receptors in B-cell memory independent of CD19.
  • B-cell transmembrane molecule that is critical for B-cell activation
  • functions in a complex with CD21, CD81, and CD225 to signal with the B cell receptor upon antigen recognition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • importance of interaction of complement receptors and CD19 for coreceptor activity in humoral immunity
  • interaction with CD81 (CD81 gene defect disrupts CD19 complex formation and leads to antibody deficiency)
  • direct target of PAX5 in cells with and without the t(8;21) chromosomal translocation
  • PAX5 binds to the promoter and enhancer of CD19 gene and remodels chromatin structure at the promoter
  • cell & other
    REGULATION
    Other differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS