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FLASH GENE
Symbol CCNH contributors: - updated : 18-05-2011
HGNC name cyclin H
HGNC id 1594
Location 5q14.3      Physical location : 86.690.082 - 86.708.836
Synonym symbol(s) CYCH, CAK, P34, P37
DNA
TYPE functioning gene
STRUCTURE 18.75 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CKMT2 5q13.3 creatine kinase, mitochondrial 2 (sarcomeric) DKFZp761J139 5q14.1 hypothetical protein DKFZp761J139 CACH-1 5q14.1 cytosolic acetyl-CoA hydrolase SSBP2 5q14.1 single-stranded DNA binding protein 2 DSS1P1 5q14 single-stranded DNA binding protein 2 APG10L 5q14.1 APG10 autophagy 10-like (S. cerevisiae) PPIP1 5q14.1 peptidylprolyl isomerase (cyclophilin) pseudogene 1 RPS23 5q13-q14 ribosomal protein S23 LOC92270 5q14.1 hypothetical protein LOC92270 LOC389307 5 LOC389307 LOC391806 5 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein MGC23909 5q14.2 hypothetical protein MGC23909 XRCC4 5q11.2-q13.3 X-ray repair complementing defective repair in Chinese hamster cells 4 CSPG2 5q14.3 chondroitin sulfate proteoglycan 2 (versican) CRTL1 5q14.3 cartilage linking protein 1 EDIL3 5q14 EGF-like repeats and discoidin I-like domains 3 LOC391807 5 similar to peptidyl-Pro cis trans isomerase LOC391808 5 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC391809 5 similar to 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) MGC48637 5q14.3 hypothetical protein MGC48637 COX7C 5q14 cytochrome c oxidase subunit VIIc LOC389308 5 similar to ribosomal protein L10a FLJ11292 5q14.3 hypothetical protein FLJ11292 RASA1 5q13.3 RAS p21 protein activator (GTPase activating protein) 1 CCNH 5q13.3-q14 cyclin H MGC33214 5q14.3 hypothetical protein MGC33214 MEF2C 5q14 MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) CETN3 5q14.3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast) LOC153364 5q14.3 similar to metallo-beta-lactamase superfamily protein like (XL884) RPC32 5q14.3 polymerase (RNA) III (DNA directed) (32kD) LOC116068 5q14.3 hypothetical protein LOC116068 MASS1 5q14.1 monogenic, audiogenic seizure susceptibility 1 homolog (mouse) LOC133790 5q14.3 similar to ribosomal protein S18, cytosolic [validated] - rat KIAA1376 LOC133789 5q14.3 similar to Rab5c protein LOC391810 5 similar to T-complex protein 1, eta subunit (TCP-1-eta) (CCT-eta) (HIV-1 Nef interacting protein) LOC391811 5 similar to DNA polymerase delta subunit 2 NR2F1 5q14 nuclear receptor subfamily 2, group F, member 1 LOC389309 5 LOC389309 DKFZP564D172 5q15 hypothetical protein DKFZp564D172
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1398 - 323 - 1998 9465303
- - 1517 - 270 - 1998 9465303
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
interspecies homolog to murine Ccnh
homolog to C.elegans Y49f6b.1
Homologene
FAMILY
  • cyclin family
  • cyclin c subfamily
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • transcription,DNA repair
  • putatively involved in cell cycle control
  • CELLULAR PROCESS cell cycle, progression
    nucleotide, repair
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a ternary complex with CDK7 and MNAT1 (see symbols)forming CDK activating kinase (CAK1)
  • trimeric CDK7/cyclin H/MNAT1 complex functions in cell cycle regulation, as the Cdk-activating kinase, and in transcription, as a module of the general transcription factor TFIIH )
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating in the multisubunit complex TFIIH (GTF2H)
  • CDK7 and MNAT1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    and is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS