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FLASH GENE
Symbol CCNH contributors: - updated : 18-05-2011
HGNC name cyclin H
HGNC id 1594
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
interspecies homolog to murine Ccnh
homolog to C.elegans Y49f6b.1
Homologene
FAMILY
  • cyclin family
  • cyclin c subfamily
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • transcription,DNA repair
  • putatively involved in cell cycle control
    • CELLULAR PROCESS cell cycle, progression
    nucleotide, repair
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a ternary complex with CDK7 and MNAT1 (see symbols)forming CDK activating kinase (CAK1)
  • trimeric CDK7/cyclin H/MNAT1 complex functions in cell cycle regulation, as the Cdk-activating kinase, and in transcription, as a module of the general transcription factor TFIIH )
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating in the multisubunit complex TFIIH (GTF2H)
  • CDK7 and MNAT1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    and is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS