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FLASH GENE
Symbol CCND3 contributors: mct - updated : 30-08-2016
HGNC name cyclin D3
HGNC id 1585
Location 6p21.1      Physical location : 41.902.671 - 42.016.610
Synonym name G1/S-specific cyclin D3
Synonym symbol(s) CGD3
DNA
TYPE functioning gene
STRUCTURE 113.96 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
UNC5CL 6p21.1 unc-5 homolog C (C. elegans)-like BZRPL1 6p21.1 benzodiazapine receptor (peripheral)-like 1 APOBEC2 6p21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 C6orf130 6p21.1 chromosome 6 open reading frame 130 NFYA 6p21.3 nuclear transcription factor Y, alpha LOC221442 6p21.1 hypothetical protein LOC221442 TREML1 6p21.1 triggering receptor expressed on myeloid cells-like 1 TREM2 6p21.1 triggering receptor expressed on myeloid cells 2 C6orf76 6p21.1 chromosome 6 open reading frame 76 LOC285852 6p21.1 hypothetical protein LOC285852 TREM1 6p21.1 triggering receptor expressed on myeloid cells 1 NCR2 6p21.1 natural cytotoxicity triggering receptor 2 FOXP4 6p21.1 forkhead box P4 MDFI 6p21 MyoD family inhibitor TFEB 6p21 transcription factor EB PGC 6p22-p12 progastricsin (pepsinogen C) FRS3 6p21.1 fibroblast growth factor receptor substrate 3 C6orf49 6p21.31 chromosome 6 open reading frame 49 MGC20741 6p21 ubiquitin specific protease 49 USP49 6p12.1 ubiquitin specific protease 49 BYSL 6p21.1 bystin-like CCND3 6p21 cyclin D3 TBN 6p21.1 taube nuss homolog (mouse) LOC389389 6 similar to hypothetical protein BC006605 GUCA1A 6p21.1 guanylate cyclase activator 1A (retina) GUCA1B 6p21.1 guanylate cyclase activator 1B (retina) MRPS10 6p21.1-p12.1 mitochondrial ribosomal protein S10 TRERF1 6p21.1-p12.1 transcriptional regulating factor 1 C6orf133 6p21.1 chromosome 6 open reading frame 133 RDS 6p21.2-p11.1 retinal degeneration, slow LOC391920 6 similar to Vacuolar ATP synthase 16 kDa proteolipid subunit TBCC 6p21.1 tubulin-specific chaperone c KIAA0240 6p21.1 KIAA0240
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1888 - 96 - 2001 11418483
5 - 2116 - 211 - 2001 11418483
4 - 1879 - 220 - 2001 11418483
5 - 2095 - 292 - 2001 11418483
5 - 2065 - 96 - 2001 11418483
5 - 2585 - 242 - 2001 11418483
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunespleen   highly
 thymus   highly
 tonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Ccnd3
Homologene
FAMILY
  • family of mitogen-activated D-type cyclins
  • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • regulator of progression through G1 phase during the cell cycle 3
  • involved in the loss of cell cycle control in a small fraction of malignant glioma
  • having important implications for a role for lamin A/C in muscle differentiation
  • playing a crucial role in adipocyte differentiation by regulating mitotic clonal expansion
  • central coordinator that controls the organization of a complex set of proteins that regulate autophagy, formation of the monocyte-adhesive hyaluronan matrix, and CEBPA-mediated lipogenesis
  • role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis
  • primary driver of the cell cycle, in cooperation with CCND1 that integrates extracellular mitogenic signaling
  • predominantly regulate progression through the cell cycle by their interactions with cyclin-dependent kinases (CDKs)
  • uniquely required for germinal center progression
  • selectively required for proliferative expansion of germinal center B cells
  • primes myoblasts for differentiation by enhancing muscle specific gene expression and cell cycle exit
  • CCND3 and its partner CDK6 were required for the proliferation of Burkitt lymphoma (BL)
  • regulates the number of cell divisions that erythroid precursors undergo during terminal differentiation, thereby controlling erythrocyte size and number
  • likely subnuclear compartmentalization enables CCND3 to drive cell cycle progression and repress V gene accessibility, thereby ensuring coordination of proliferation with immunoglobulin recombination
  • critically required for proper developmental progression of myogenic progenitors
  • plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CCND3/CDK11A complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK4 and CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex
  • binding to LMNA
  • binding partner of MAPK4
  • key direct target of TCF3 is CCND3, a regulator of the G1-S phase transition that is required for an effective germinal center reaction
  • nuclear IGF2BP3-HNRNPM complex is important for the efficient synthesis of CCND1, CCND3 and CCNG1 and for the proliferation of human cancer cells
  • CCND3 protein that drives immature T cell proliferation is essential for transformation of ATM-deficient thymocytes
  • DYRK1A restrains CCND3 protein levels by phosphorylating T283 to induce its degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    with CDKN1B in agressive B cell lymphoma, glioblastoma and gliosarcoma
    tumoral   translocation    
    in multiple myeloma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    potential therapeutic target for germinal center-derived B-cell malignancies
    ANIMAL & CELL MODELS
    Ccnd3(-/-) mice exhibit a B-cell-intrinsic defect in germinal center maturation and fail to generate an affinity-matured IgG response