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FLASH GENE

Symbol

CCL8

contributors: npt/ - updated : 25-09-2007

HGNC name	chemokine (C-C motif) ligand 8
HGNC id	10635

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q11.2      Physical location : 32.646.065 - 32.648.419
Synonym name	small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
	monocyte chemotactic protein 2
	small inducible cytokine A8
Synonym symbol(s)	HC14, MCP2, MCP-2, SCYA8, SCYA10

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered in IMC1@
STRUCTURE	2.36 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map

see IMG1@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Variant 1 3 - 1351 8.9 99 - Van coillie

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       lowly   thymus       moderately Cardiovascular heart       moderately Digestive intestine small intestine     predominantly   intestine large intestine colon   moderately   liver       lowly Endocrine pancreas       moderately Nervous brain       lowly   spinal cord       moderately Reproductive female system ovary     moderately   male system prostate     lowly Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial secretory glandular endocrine   Lymphoid         Muscular striatum skeletal     Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta (moderately)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , monomer , dimer

HOMOLOGY

interspecies	homolog to Drosophila eg:bacr25b3.3
	homolog to C.elegans K02e7.11

intraspecies	homolog to CCL7
	homolog to CCL2

Homologene

FAMILY	intercrine beta family
	small cytokines C-C subfamily

CATEGORY

immunity/defense , signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
text	secreted

basic FUNCTION	may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection
	chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils

CELLULAR PROCESS	cell communication
	cell migration & motility

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

text	immunoregulatory and inflammatory processes
	calcium CA2+ homeostasis

PATHWAY

metabolism

signaling

signal transduction

cell-cell signaling

a component

monodimer or homodimer in equilibrium

INTERACTION

DNA

RNA

small molecule

protein

binding to heparin, CCR1, CCR2B

cell & other

REGULATION

induced by

interferon gamma,mitogens,interleukin-1

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS