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FLASH GENE
Symbol CCL8 contributors: npt/ - updated : 25-09-2007
HGNC name chemokine (C-C motif) ligand 8
HGNC id 10635
Location 17q11.2      Physical location : 32.646.065 - 32.648.419
Synonym name
  • small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
  • monocyte chemotactic protein 2
  • small inducible cytokine A8
  • Synonym symbol(s) HC14, MCP2, MCP-2, SCYA8, SCYA10
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered in IMC1@
    STRUCTURE 2.36 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see IMG1@
    Physical map
    SPACA3 17q12 sperm acrosome associated 3 ACCN1 17q11.2-q12 amiloride-sensitive cation channel 1, neuronal (degenerin) LOC339212 17q12 similar to tousled-like kinase 2; serine/threonine kinase; tousled-like kinase CCL2 17q11.2-q21.1 chemokine (C-C motif) ligand 2 CCL7 17q11.2-q12 chemokine (C-C motif) ligand 7 CCL11 17q21.1-q21.2 chemokine (C-C motif) ligand 11 CCL8 17q11.2 chemokine (C-C motif) ligand 8 CCL13 17q11.2 chemokine (C-C motif) ligand 13 CCL1 17q11.2 chemokine (C-C motif) ligand 1 LOC124842 17q12 hypothetical protein LOC124842 CCT6B 17q11.2 chaperonin containing TCP1, subunit 6B (zeta 2) MGC20398 17q21.1 hypothetical protein MGC20398 LIG3 17q11.2-q12 ligase III, DNA, ATP-dependent LOC117584 17q21.1 fring RAD51L3 17q11 RAD51-like 3 (S. cerevisiae) DKFZp434H2215 17q21.1 hypothetical protein DKFZp434H2215 FLJ10458 17q21.1 Notchless gene homolog (Drosophila) CMYA4 17q21.1 cardiomyopathy associated 4 FLJ40154 17q21.1 hypothetical protein FLJ40154 MGC19764 17q21.1 hypothetical protein MGC19764 FLJ34922 17q21.1 hypothetical protein FLJ34922 FLJ10260 17q21.1 hypothetical protein FLJ10260 FLJ31952 17q21.1 hypothetical protein FLJ31952 LOC342615 17q21.1 similar to Adenylosuccinate synthetase 2 (IMP--aspartate ligase 2) (AdSS 2) (AMPSase 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1351 8.9 99 - Van coillie
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
     thymus   moderately
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  predominantly
     intestinelarge intestinecolon moderately
     liver   lowly
    Endocrinepancreas   moderately
    Nervousbrain   lowly
     spinal cord   moderately
    Reproductivefemale systemovary  moderately
     male systemprostate  lowly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta (moderately)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , monomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila eg:bacr25b3.3
    homolog to C.elegans K02e7.11
    intraspecies homolog to CCL7
    homolog to CCL2
    Homologene
    FAMILY
  • intercrine beta family
  • small cytokines C-C subfamily
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection
  • chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text
  • immunoregulatory and inflammatory processes
  • calcium CA2+ homeostasis
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
  • monodimer or homodimer in equilibrium
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin, CCR1, CCR2B
  • cell & other
    REGULATION
    induced by interferon gamma,mitogens,interleukin-1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS