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FLASH GENE
Symbol CCL8 contributors: npt/ - updated : 25-09-2007
HGNC name chemokine (C-C motif) ligand 8
HGNC id 10635
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1351 8.9 99 - Van coillie
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
 thymus   moderately
Cardiovascularheart   moderately
Digestiveintestinesmall intestine  predominantly
 intestinelarge intestinecolon moderately
 liver   lowly
Endocrinepancreas   moderately
Nervousbrain   lowly
 spinal cord   moderately
Reproductivefemale systemovary  moderately
 male systemprostate  lowly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Lymphoid    
Muscularstriatumskeletal  
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta (moderately)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , monomer , dimer
HOMOLOGY
interspecies homolog to Drosophila eg:bacr25b3.3
homolog to C.elegans K02e7.11
intraspecies homolog to CCL7
homolog to CCL2
Homologene
FAMILY
  • intercrine beta family
  • small cytokines C-C subfamily
    CATEGORY immunity/defense , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection
  • chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils
  • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text
  • immunoregulatory and inflammatory processes
  • calcium CA2+ homeostasis
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
  • monodimer or homodimer in equilibrium
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to heparin, CCR1, CCR2B
  • cell & other
    REGULATION
    induced by interferon gamma,mitogens,interleukin-1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS