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FLASH GENE
Symbol CCL19 contributors: mct/npt - updated : 21-02-2012
HGNC name chemokine (C-C motif) ligand 19
HGNC id 10617
Location 9p13      Physical location : 34.689.568 - 34.691.274
Synonym name
  • exodus 3
  • macrophage inflammatory protein 3 beta
  • EBT1 ligand chemokine
  • small inducible cytokine subfamily A (Cys-Cys), member 19
  • CK beta-11
  • Synonym symbol(s) ELC, CKb11, MIP3B, MIP-3b, SCYA19, MGC34433
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 1.71 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    Physical map
    C9orf48 9p13.2 chromosome 9 open reading frame 48 KIF24 9p13.2 kinesin family member 24 NUDT2 9p13 nudix (nucleoside diphosphate linked moiety X)-type motif 2 KIAA1161 9p11.2 KIAA1161 C9orf24 9p11.2 chromosome 9 open reading frame 24 C9orf25 9p11.2 chromosome 9 open reading frame 25 DNAI1 9p13.3 dynein, axonemal, intermediate polypeptide 1 UNQ470 9p13.2 GAAI470 CNTFR 9p21-p13 ciliary neurotrophic factor receptor C9orf23 9p11.2 chromosome 9 open reading frame 23 DCTN3 9p13 dynactin 3 (p22) LOC138715 9p13.2 similar to E2F binding protein OPRS1 9 opioid receptor, sigma 1 GALT 9p13.3 galactose-1-phosphate uridylyltransferase IL11RA 9p13 interleukin 11 receptor, alpha CCL27 9p13 chemokine (C-C motif) ligand 27 LOC389714 9 LOC389714 CCL19 9p13 chemokine (C-C motif) ligand 19 CCL21 9p13 chemokine (C-C motif) ligand 21 LOC259308 9p12 DKFZP434J193-like pseudogene LOC389715 9 hypothetical gene supported by AK128180 LOC392305 9 similar to GLUL protein LOC158383 9p13.2 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene KIAA1045 9p13.2 KIAA1045 DNAJB5 9p11.2 DnaJ (Hsp40) homolog, subfamily B, member 5 LOC392306 9 similar to GCIP-interacting protein p29
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 684 11 98 - 2008 18047937
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     stomach   lowly
    Lymphoid/Immunelymph node    
     spleen   highly
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative signal sequence
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Scya19
    Homologene
    FAMILY
  • small inducible cytokine, chemokine beta, CC subfamily
  • CATEGORY signaling cytokine , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • key factor enabling all these early T cell responses, including the occurrence of calcium transients
  • promotes Ag-independent responses and increases the probability of cognate MHC-peptide encounter
  • macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal
  • CCL19/21 induced PI3K-dependent phosphorylation of Akt/protein kinase B, activation of the Rho/Rho-associated coiled-coil forming protein kinases/myosin light chain pathway and MAPKs phosphorylation
  • CCL21 together with another CCR7 ligand, CCL19, direct the navigation and compartmentation of T cells within secondary lymphoid tissues
  • controls signaling events in T cells
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense
    text immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • part of CCL19, CCL21/CCR7 chemokine system expressed in inflamed muscles of polymyositis and may be involved in the pathomechanism of polymyositis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for the orphan receptor EBI1 (CMKBR7)
  • ligand of CCR7
  • specific ligand for CCRL2 (CCL19 is known to be critically involved in lymphocyte and dendritic cell trafficking, and CCL19-binding competition by CCRL2 might be involved in modulating these processes)
  • FHL2 is a novel regulator of CCL19-induced dendritic cell (DC) migration
  • CCL19 stimulation of na
  • ve T cells regulates expression of MAPK7, KLF2, and S1PR1
  • CCL19 controls T cell regulation of S1PR1 expression
  • after binding to CCL19, CCR7 signaling leads to increased expression and phosphorylation of MAPK7 and up-regulation of KLF2, which results in S1PR1 expression and a migration of T lymphocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS