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FLASH GENE
Symbol CCL19 contributors: mct/npt - updated : 21-02-2012
HGNC name chemokine (C-C motif) ligand 19
HGNC id 10617
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 684 11 98 - 2008 18047937
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 stomach   lowly
Lymphoid/Immunelymph node    
 spleen   highly
Respiratorylung   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative signal sequence
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Scya19
    Homologene
    FAMILY
  • small inducible cytokine, chemokine beta, CC subfamily
  • CATEGORY signaling cytokine , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • key factor enabling all these early T cell responses, including the occurrence of calcium transients
  • promotes Ag-independent responses and increases the probability of cognate MHC-peptide encounter
  • macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal
  • CCL19/21 induced PI3K-dependent phosphorylation of Akt/protein kinase B, activation of the Rho/Rho-associated coiled-coil forming protein kinases/myosin light chain pathway and MAPKs phosphorylation
  • CCL21 together with another CCR7 ligand, CCL19, direct the navigation and compartmentation of T cells within secondary lymphoid tissues
  • controls signaling events in T cells
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS immunity/defense
    text immune response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • part of CCL19, CCL21/CCR7 chemokine system expressed in inflamed muscles of polymyositis and may be involved in the pathomechanism of polymyositis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for the orphan receptor EBI1 (CMKBR7)
  • ligand of CCR7
  • specific ligand for CCRL2 (CCL19 is known to be critically involved in lymphocyte and dendritic cell trafficking, and CCL19-binding competition by CCRL2 might be involved in modulating these processes)
  • FHL2 is a novel regulator of CCL19-induced dendritic cell (DC) migration
  • CCL19 stimulation of na
  • ve T cells regulates expression of MAPK7, KLF2, and S1PR1
  • CCL19 controls T cell regulation of S1PR1 expression
  • after binding to CCL19, CCR7 signaling leads to increased expression and phosphorylation of MAPK7 and up-regulation of KLF2, which results in S1PR1 expression and a migration of T lymphocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS