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FLASH GENE
Symbol CBR1 contributors: mct - updated : 02-02-2008
HGNC name carbonyl reductase 1
HGNC id 1548
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Nervousbrain   highly
 nerve   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies homolog to murine Cbr1
homolog to C.elegans F20G2.1
Homologene
FAMILY short chain dehydrogenases/reductases (SDR) family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • NADPH-dependent oxidoreductase
  • metabolizing endogenous and xenobiotic substrates such as the fever mediator, prostaglandin E2 (PGE2), and the anticancer anthracycline drug, daunorubicin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , lipid/lipoprotein
    signaling
    metabolism of many carbonyl compounds, including antitumor anthracycline antibiotics
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH
    protein
    cell & other
    REGULATION
    induced by BHA,beta-naphthoflavone,sudan 1
    Other regulated by the aryl hydrocarbon receptor (AHR)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Down Syndrome (DS) and Alzheimer's Disease (AD) brains
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS