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FLASH GENE
Symbol CAT contributors: - updated : 19-10-2020
HGNC name catalase
HGNC id 1516
Corresponding disease
CAT acatalasia
Location 11p13      Physical location : 34.460.471 - 34.493.606
Synonym symbol(s) MGC138422, MGC138424
EC.number 1.11.1.6
DNA
TYPE functioning gene
STRUCTURE 33.13 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure
  • housekeeping gene (no TATA box, no initiator element sequence, high GC content in promoter) and a core promoter that is highly conserved among species
  • MAPPING cloned Y linked Y status confirmed
    Map pter - LMO2 - D11S318 - D11S153 - D11S907 - CAT CAT - CD44 - D11S9 - ACP2 ACP2 - D11S33 - cen
    Authors Glaser (89), Gawin (95)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2291 - 527 - 2019 30600457
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies ortholog to murine Cat
    ortholog to dog cat
    Homologene
    FAMILY catalase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in catabolic pathway of activated oxygen species and free radical detoxification
  • catalase overexpression has a protective role against UVB irradiation by preventing DNA damage mediated by the late ROS increase
  • catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species
  • heme enzymes, which catalyze decomposition of hydrogen peroxide to water and molecular oxygen
  • is an important antioxidant enzyme that dismutates hydrogen peroxide into water and molecular oxygen
  • catalase is a key enzyme in the metabolism of H2O2 and reactive nitrogen species, and its expression and localization is markedly altered in tumors
  • major peroxisome protein, plays a critical role in removing peroxisome-generated reactive oxygen species (ROS) produced by peroxisome enzymes
  • catalase plays an important role in pexophagy during nutrient deprivation
  • potential therapeutic effects in nonalcoholic fatty liver disease (NAFLD) progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    heme group and NADP
    protein
  • transcription factors (PPARG,POU2F1), as well as genetic, epigenetic, and posttranscriptional processes, have emerged as crucial contributors to the regulation of catalase expression (PIMID: 26117330)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAT
    Susceptibility
  • to essential hypertension
  • to noise-induced hearing loss
  • Variant & Polymorphism
    Candidate gene
  • neurocognitive sequelae associated with radiation exposure can be reduced by overexpression of Mitochondrial CAT, operating through a mechanism involving the preservation of neuronal morphology
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice devoid of catalase develop an obese, pre-diabetic phenotype