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FLASH GENE
Symbol CAT contributors: - updated : 30-01-2007
HGNC name catalase
HGNC id 1516
Corresponding disease
CAT acatalasia
Location 11p13      Physical location : 34.460.471 - 34.493.606
Synonym symbol(s) MGC138422, MGC138424
EC.number 1.11.1.6
DNA
TYPE functioning gene
STRUCTURE 33.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map pter - LMO2 - D11S318 - D11S153 - D11S907 - CAT CAT - CD44 - D11S9 - ACP2 ACP2 - D11S33 - cen
Authors Glaser (89), Gawin (95)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer homomer , tetramer
HOMOLOGY
interspecies ortholog to murine Cat
ortholog to dog cat
Homologene
FAMILY catalase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,peroxisome
basic FUNCTION
  • involved in catabolic pathway of activated oxygen species and free radical detoxification
  • catalase overexpression has a protective role against UVB irradiation by preventing DNA damage mediated by the late ROS increase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    heme group and NADP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAT
    Susceptibility
  • to essential hypertension
  • to noise-induced hearing loss
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS