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FLASH GENE
Symbol CASP5 contributors: mct/npt/shn - updated : 05-04-2015
HGNC name caspase 5, apoptosis-related cysteine peptidase
HGNC id 1506
Location 11q22.3      Physical location : 104.864.966 - 104.893.895
Synonym name
  • caspase 5, apoptosis-related cysteine protease
  • interleukin 1 beta-convertase, related cell death 3
  • ICH-3 protease
  • protease ICH-3
  • ICE(rel)-III
  • caspase-5 subunit p20
  • caspase-5 subunit p10
  • CASP-5
  • caspase-5
  • TY protease
  • protease TY
  • apoptosis-related cysteine protease
  • Synonym symbol(s) ICER3, ICE(rel)III, ICH-3, MGC141966
    EC.number 3.4.22.36, 3.4.22.58
    DNA
    TYPE functioning gene
    STRUCTURE 29.67 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S4951 - D11S1886 - CASP5 - D11S2000 - D11S1781 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 1028 - 292 - 2018 29715460
    8 splicing 1165
    9 splicing 1275 - 376 - 2018 29715460
    7 splicing 913
    10 splicing 1488 - 447 - 2018 29715460
    10 splicing 1449 - 434 - 2018 29715460
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly Homo sapiens
    Endocrinepancreas   lowly Homo sapiens
    Reproductivefemale systemplacenta  moderately Homo sapiens
    Respiratorylung   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal (Fas-associating protein with DEATH domain) FADD-like death effector domain
  • a conserved QACXG pentapeptide active site motif
  • an (A) 10 repeat within its coding region
  • mono polymer heteromer , tetramer
    isoforms Precursor precursor producing two subunits,large (20kDa) and small (10kDa) that dimerize
    HOMOLOGY
    interspecies ortholog to CASP5, pan troglodytes
    Homologene
    FAMILY
  • caspase family of cysteinyl-aspartate specific proteases
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,cytosolic
    text stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli
    basic FUNCTION
  • caspase 5, cysteine containing aspartate-specific protease, inducing apoptosis in fibroblast, lacking convertase activity
  • potentially involved in procytokine activation
  • may be a suppressor gene of highly metastatic potential in lung cancer
  • having pro-apoptotic and pro-inflammatory activities
  • changes of CASP2 and CASP5 activities could be indicative of their involvement in the cervical malignancy mechanisms
  • CASP5 and the inflammasome may have an important role in the inflammatory response in psoriasis
  • concerted endoproteolytic activity of CASP5 and CASP10
  • may work predominantly in concert with caspase-1 in modulating human retinal pigment epithelial inflammatory responses (
  • both CASP4 and CASP5 are functionally important for appropriate responses to intracellular Gram-negative bacteria
  • mainly participates in cell growth, apoptosis and other physiological process
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaves and activates MAX after FXS mediated dephosphorylation (
  • cleaves Periphilin (
  • NACHT, LRR and PYD containing protein 1, NALP1 (
  • CASP4 and caspase-5 mediate IL1A and IL1B release from human monocytes after lipopolysaccharide (LPS) stimulation
  • CASP4, CASP5, and SCAF11 directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors
  • IL17A promoted CASP5 function via facilitation of the NLRP1-inflammasome
  • cell & other
    REGULATION
    Other regulated by IFNG and lipopolysaccharide
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastoma multiforme
    constitutional     --over  
    can promote the angiogenesis significantly, possibly by inhibiting the ANGPT1/TEK pathway and promoting VEGFA pathway
    constitutional     --over  
    in lesional psoriatic skin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mutated in lung cancer with highly metastatic potential in lung cancer