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FLASH GENE

Symbol

CASP10

contributors: mct - updated : 18-04-2015

HGNC name	caspase 10, apoptosis-related cysteine protease
HGNC id	1500

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ALPS2 autoimmune inherited lymphoproliferative syndrome, type II
Location	2q33.1      Physical location : 202.047.620 - 202.094.110
Synonym name	FADD homologous-like protease
	apoptotic protease Mch-4
	ICE-like apoptotic protease 4
	FAS-associated death domain protein interleukin-1B-converting enzyme
	2
Synonym symbol(s)	MCH4, FLICE2, ALPS2
EC.number	3.4.22.36

DNA

TYPE	functioning gene
STRUCTURE	38.77 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032974 10 splicing 2288 58.9 521 - 2011 21368896 lacking exon 10 distinct C terminus CASP10B had no effect or were weakly anti-apoptotic its unique C-terminal end was responsible for its degradation by the ubiquitin-proteasome pathway and for its lack of pro-apoptotic activity compared with caspase-10A and -10D NM_001230 8 splicing 5777 54.6 479 - 2011 21368896 lacking exons 6, 7 and 43 internal AA CASP10A strongly increased TRAIL and FasL sensitivity NM_032977 10 splicing 5906 59 522 - 2011 21368896 full lenght CASP10D strongly increased TRAIL and FasL sensitivity

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Nervous brain         Reproductive male system prostate         male system testis       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines	chronic myelogenous leukemia cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text

lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two N terminal FADD-like DEATH effector domains
	a conserved QACXG pentapeptide active site motif

mono polymer

heteromer , dimer

isoforms

Precursor

HOMOLOGY

interspecies

homolog to C.elegans Ced-3

Homologene

FAMILY

peptidase C14 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
text	stored in the mitochondrial intermembrane space and released into cytosol after appropriate apoptotic stimuli

basic FUNCTION	recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis
	CASP8 and CASP10 may be involved in the pathogenesis of rectal cancer
	involved in the extrinsic death receptor pathway
	prodeath role for both cleaved and uncleaved CASP10
	may play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria
	concerted endoproteolytic activity of CASP5 and CASP10

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	can serve as an initiator caspase in Fas signaling leading to Bid processing, caspase cascade activation, and apoptosis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	activating CASP3 and CASP7
	ABCF1, AKAP1, CPE, DOPEY1 and GOPC may be targeted specifically by the initiator CASP8 and CASP10 during the early stages of apoptosis
	RIOK3 interacted with caspase-10 (interaction was mediated by the RIO domain of RIOK3 and each death effector domain of CASP10)
	CASP10 negatively regulates CASP8-mediated cell death
	CASP8 is required upstream of both CFLAR and CASP10 and death-inducing signaling complex (DISC) formation critically depends on the scaffold function of CASP8

cell & other

REGULATION

activated by	CASP9
	CASP8 which cleaved caspase-10 directly

ASSOCIATED DISORDERS

corresponding disease(s)

ALPS2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in term placentas from women with pregnancies complicated by preeclampsia tumoral somatic mutation       CASP10 mutation might contribute to the pathogenesis of some colon carcinomas together with other CASP gene mutations (CASP3, CASP7, CASP8) tumoral somatic mutation       CASP10 mutation might contribute to the pathogenesis of factions of T-ALL and multiple myelomas

Susceptibility

to breast cancer

Variant & Polymorphism other	polymorphisms significantly associated with a highly decreased familial breast cancer risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS