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FLASH GENE
Symbol CARTPT contributors: mct/npt - updated : 05-02-2010
HGNC name CART prepropeptide
HGNC id 24323
Location 5q13.1      Physical location : 71.014.989 - 71.016.875
Synonym name
  • amphetamine and cocaine regulated transcript
  • cocaine- and amphetamine-regulated transcript
  • Synonym symbol(s) ARCT, CART
    DNA
    TYPE functioning gene
    STRUCTURE 1.88 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 933 - 116 - Douglass (1996)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Nervousbraindiencephalonhypothalamus specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure compact structure containing three disulfide bridges is necessary for preservation of full biological activity of CARTPT (Maixnerova 2007)
    HOMOLOGY
    interspecies homolog to rattus Cart
    Homologene
    FAMILY
  • CART family
  • CATEGORY regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • satiety factor, anorexigenic peptide responding to leptin
  • regulating bone resorption independently of the role it may exert in energy metabolism
  • plays an important role in the hypothalamic regulation of energy balance by reducing food intake and increasing lipid substrate utilization
  • inhibits expression of Neuropeptide Y (NPY) and induces expression of uncoupling proteins
  • involved in reward and feeding behavior and has functional characteristics of an endogenous psychostimulant (Lohoff 2008)
  • plays an important role in the hypothalamic regulation of energy balance by reducing food intake and increasing lipid substrate utilization (Vasseur 2007)
  • potential implication in lipid metabolism and in atherogenesis (Vasseur 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein leptin
    cell & other
    REGULATION
    Other amphetamine and cocaine regulated transcript
    regulated by circulating leptin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to obesity
  • to atherogenesis
  • Variant & Polymorphism SNP , other
  • L34F increase the risk of obesity
  • SNP 3608C>T) associated with lower plasma LDL-cholesterol levels suggesting protection against the development of atherogenesis
  • Candidate gene
  • reduced CARTPT is a sign of hypothalamic dysfunction in dementia with Lewy bodies and may serve as a biomarker for this patient group (Schulz 2009)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS