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FLASH GENE
Symbol CAPZA2 contributors: mct - updated : 15-03-2008
HGNC name capping protein (actin filament) muscle Z-line, alpha 2
HGNC id 1490
Location 7q31.2-q31.3      Physical location : 116.502.562 - 116.559.312
Synonym name
  • F-actin capping protein alpha-2 subunit
    • Synonym symbol(s) CAPPA2, CAPZ
    DNA
    TYPE functioning gene
    STRUCTURE 56.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - GAS7A - MET -D7S2460 - GAS7B - CAPZA2 - D7S122 - WNT2 - D7S633 - D7S677 /CFTR - qter
    Authors Barron-Casella (95),Mueller (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2373 - 286 - Ewing (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestine   highly
     pharynx   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Caz2
    Homologene
    FAMILY F-actin capping protein alpha subunit family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION F-actin-capping protein that bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments,
    thereby blocking the exchange of subunits at these ends
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer of an alpha and a beta subunit
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS