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FLASH GENE
Symbol CAPZA2 contributors: mct - updated : 15-03-2008
HGNC name capping protein (actin filament) muscle Z-line, alpha 2
HGNC id 1490
DNA
TYPE functioning gene
STRUCTURE 56.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - GAS7A - MET -D7S2460 - GAS7B - CAPZA2 - D7S122 - WNT2 - D7S633 - D7S677 /CFTR - qter
Authors Barron-Casella (95),Mueller (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2373 - 286 - Ewing (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestine   highly
 pharynx   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Caz2
Homologene
FAMILY F-actin capping protein alpha subunit family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION
basic FUNCTION F-actin-capping protein that bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments,
thereby blocking the exchange of subunits at these ends
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component heterodimer of an alpha and a beta subunit
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS