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FLASH GENE
Symbol CAP1 contributors: mct - updated : 03-05-2017
HGNC name CAP, adenylate cyclase-associated protein 1 (yeast)
HGNC id 20040
Location 1p34.3      Physical location : 40.506.254 - 40.538.323
Synonym name
  • adenyl cyclase associated protein, 70 kDa subunit
  • testis secretory sperm-binding protein Li 218p
  • Synonym symbol(s) ACAP, CAP, CAP1-PEN
    DNA
    TYPE functioning gene
    STRUCTURE 32.58 kb     13 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BMP8A 1p34.2 bone morphogenetic protein 8a OXCT2P 1p34.2 3-oxoacid CoA transferase 2 pseudogene FLJ14351 1p34.2 hypothetical protein FLJ14351 PABPC4 1p36-p32 poly(A) binding protein, cytoplasmic 4 (inducible form) HEYL 1p34.3 hairy/enhancer-of-split related with YRPW motif-like NT5C1A 1p34.3-p33 5'-nucleotidase, cytosolic IA HPCAL4 1p34.2 hippocalcin like 4 PPIE 1p32 peptidylprolyl isomerase E (cyclophilin E) BMP8B 1p35-p32 bone morphogenetic protein 8 b(osteogenic protein 2) OXCT2 1p34 3-oxoacid CoA transferase 2 IPT 1p35.3-p34.1 3-oxoacid CoA transferase 2 MYCL1 1p34.2 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) FLJ14490 1p34.2 hypothetical protein FLJ14490 CAP1 1p34.2 CAP, adenylate cyclase-associated protein 1 (yeast) PPT1 1p32 palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) RLF 1p32 rearranged L-myc fusion sequence LOC127391 1p34.2 similar to dJ39G22.2 (novel protein) ZMPSTE24 1p34.1-p33 zinc metalloproteinase (STE24 homolog, yeast) COL9A2 1p33-p32.3 collagen, type IX, alpha 2 LOC388621 1 similar to 60S ribosomal protein L21 LOC391028 1 similar to Csa-19 LOC64744 1p35.3-p34.1 hypothetical protein AL133206 LOC65243 1p34.2 hypothetical protein LOC65243 FLJ16030 1p34.2 FLJ16030 protein FLJ21144 1p34.2 hypothetical protein FLJ21144 MGC27466 1p34.2 hypothetical protein MGC27466 LOC391029 1 similar to General transcription factor IIF, polypeptide 2 RIMS3 1pter-p22.2 regulating synaptic membrane exocytosis 3 NFYC 1p32 nuclear transcription factor Y, gamma KCNQ4 1p34 potassium voltage-gated channel, KQT-like subfamily, member 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2798 - 475 - 2002 11950878
    13 - 2780 - 475 - 2002 11950878
    - - 2770 - 474 - 2002 11950878
    - - 2848 - 475 - 2002 11950878
    - - 2783 - 475 - 2002 11950878
    - - 2801 - 475 - 2002 11950878
    - - 2866 - 475 - 2002 11950878
    - - 2985 - 475 - 2002 11950878
    - - 2982 - 475 - 2002 11950878
    - - 2798 - 474 - 2002 11950878
    - - 2875 - 475 - 2002 11950878
    - - 2780 - 474 - 2002 11950878
    - - 2860 - 474 - 2002 11950878
    - - 2777 - 474 - 2002 11950878
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinesmall intestine  highly
    Lymphoid/Immunetonsils   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Srv2p
    ortholog to murine Cap1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in establishment and/or maintenance of cell polarity
  • playing a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin
  • CAP1 provides likely a direct link from the actin cytoskeleton to the mitochondria by functioning as an actin shuttle
  • involvement of CAP1 in the aggressive behavior of pancreatic cancer cells
  • novel cellular function for CAP1 in regulating cell adhesion
  • involved in the regulation of actin filaments, and recently reported to play a role in cell motility and the pathology of pancreatic cancer
  • is the bona fide receptor for resistin leading to inflammation
  • play a role in cell motility and in the development of certain types of cancer
  • exerts cell type-dependent functions in the invasiveness of breast cancer cells
  • functions for CAP1 in cancer cell proliferation and anchorage-independent growth, again in a cell context-dependent manner
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell polarity
    PATHWAY
    metabolism
    signaling signal transduction
    cAMP pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to adenyl cyclase , CAP2, actin
  • identified as a novel and most efficient substrate of gelatinase B/MMP9
  • actin- and cofilin-interacting protein CAP1 has a role in apoptosis
  • CAP1 is a functional receptor for RETN that directly binds to CAP1 in monocytes and upregulates cyclic AMP (cAMP) concentration, protein kinase A (PRKA) activity, and NFKB1-related transcription of inflammatory cytokine
  • cell & other
    REGULATION
    Other pPhosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human glioma
    tumoral     --over  
    is involved in the pathogenesis of epithelial ovarian cancer (EOC)
    tumoral     --over  
    might contribute heavily to the metastasis of Hepatocellular carcinoma (HCC)
    tumoral     --over  
    1 in lung cancer cells, particularly at the metastatic stage, may have significant clinical implications as a diagnostic/prognostic factor for lung cancer
    tumoral     --over  
    in pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CAP1 could be an independent prognostic factor for patients survival in Hepatocellular carcinoma (HCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    downregulation of CAP1 in tumors may serve as a treatment for glioma patients
    cancerreproductiveovary
    downregulation of CAP1 in tumor cells may be a therapeutic target for the treatment of patients with EOC
    ANIMAL & CELL MODELS