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FLASH GENE
Symbol CAP1 contributors: mct - updated : 03-05-2017
HGNC name CAP, adenylate cyclase-associated protein 1 (yeast)
HGNC id 20040
DNA
TYPE functioning gene
STRUCTURE 32.58 kb     13 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2798 - 475 - 2002 11950878
13 - 2780 - 475 - 2002 11950878
- - 2770 - 474 - 2002 11950878
- - 2848 - 475 - 2002 11950878
- - 2783 - 475 - 2002 11950878
- - 2801 - 475 - 2002 11950878
- - 2866 - 475 - 2002 11950878
- - 2985 - 475 - 2002 11950878
- - 2982 - 475 - 2002 11950878
- - 2798 - 474 - 2002 11950878
- - 2875 - 475 - 2002 11950878
- - 2780 - 474 - 2002 11950878
- - 2860 - 474 - 2002 11950878
- - 2777 - 474 - 2002 11950878
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine  highly
Lymphoid/Immunetonsils   highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast S.cerevisiae Srv2p
ortholog to murine Cap1
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
    intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • involved in establishment and/or maintenance of cell polarity
  • playing a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin
  • CAP1 provides likely a direct link from the actin cytoskeleton to the mitochondria by functioning as an actin shuttle
  • involvement of CAP1 in the aggressive behavior of pancreatic cancer cells
  • novel cellular function for CAP1 in regulating cell adhesion
  • involved in the regulation of actin filaments, and recently reported to play a role in cell motility and the pathology of pancreatic cancer
  • is the bona fide receptor for resistin leading to inflammation
  • play a role in cell motility and in the development of certain types of cancer
  • exerts cell type-dependent functions in the invasiveness of breast cancer cells
  • functions for CAP1 in cancer cell proliferation and anchorage-independent growth, again in a cell context-dependent manner
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell polarity
    PATHWAY
    metabolism
    signaling signal transduction
    cAMP pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to adenyl cyclase , CAP2, actin
  • identified as a novel and most efficient substrate of gelatinase B/MMP9
  • actin- and cofilin-interacting protein CAP1 has a role in apoptosis
  • CAP1 is a functional receptor for RETN that directly binds to CAP1 in monocytes and upregulates cyclic AMP (cAMP) concentration, protein kinase A (PRKA) activity, and NFKB1-related transcription of inflammatory cytokine
  • cell & other
    REGULATION
    Other pPhosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human glioma
    tumoral     --over  
    is involved in the pathogenesis of epithelial ovarian cancer (EOC)
    tumoral     --over  
    might contribute heavily to the metastasis of Hepatocellular carcinoma (HCC)
    tumoral     --over  
    1 in lung cancer cells, particularly at the metastatic stage, may have significant clinical implications as a diagnostic/prognostic factor for lung cancer
    tumoral     --over  
    in pancreatic cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CAP1 could be an independent prognostic factor for patients survival in Hepatocellular carcinoma (HCC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    downregulation of CAP1 in tumors may serve as a treatment for glioma patients
    cancerreproductiveovary
    downregulation of CAP1 in tumor cells may be a therapeutic target for the treatment of patients with EOC
    ANIMAL & CELL MODELS