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Symbol CAMKK2 contributors: mct - updated : 07-03-2012
HGNC name calcium/calmodulin-dependent protein kinase kinase 2, beta
HGNC id 1470
Location 12q24.31      Physical location : 121.675.495 - 121.736.111
Synonym name
  • CAMKK beta protein
  • CaM-kinase kinase beta
  • Synonym symbol(s) KIAA0787, CAMKBB, CAMKK, CAMKKB, MGC15254
    TYPE functioning gene
    STRUCTURE 60.62 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D12S366 - D12S86 - D12S349 - D12S321 - CAMKK2 - D12S342 - D12S340 - qter
    Authors Gene Map (98)
    Physical map
    COX6A1 12q24.2 cytochrome c oxidase subunit VIa polypeptide 1 HSPC132 12q24.31 hypothetical protein HSPC132 LOC387891 12 LOC387891 SFRS9 12q24.31 splicing factor, arginine/serine-rich 9 DNCL1 12q24.23 dynein, cytoplasmic, light polypeptide 1 MGC4767 12q24.31 hypothetical protein MGC4767 RNF10 12q24.2-q24.3 ring finger protein 10 POP5 12q24.31 RNase MRP/RNase P protein-like LOC390362 12 similar to 60S ribosomal protein L11 CABP1 12q24.2-q24.3 calcium binding protein 1 (calbrain) KIAA0152 12q24.31 calcium binding protein 1 (calbrain) ACADS 12q24.31-q24.32 acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain LOC387892 12 LOC387892 MGC5139 12q24.31 hypothetical protein MGC5139 SPPL3 12q24.31 SPPL3 protein LOC390363 12 similar to 60S ribosomal protein L12 FLJ38690 12q24.31 hypothetical protein FLJ38690 TCF1 12q24.2 transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor FLJ12448 12q hypothetical protein FLJ12448 OASL 12q24.2 2'-5'-oligoadenylate synthetase-like LOC390364 12 similar to 60S ribosomal protein L10 (QM protein homolog) P2RX7 12q24.2-q24.31 purinergic receptor P2X, ligand-gated ion channel, 7 P2RX4 12q24.32 purinergic receptor P2X, ligand-gated ion channel, 4 CAMKK2 12q24.32-q24.33 calcium/calmodulin-dependent protein kinase kinase 2, beta ANAPC5 12q24.2-q24.32 anaphase promoting complex subunit 5 RNF34 12q24.31 ring finger protein 34 FBXL10 12q24.31 F-box and leucine-rich repeat protein 10 FLJ14466 12q24.31 hypothetical protein FLJ14466 LOC283385 12q24.31 morn LOC144404 12q24.31 similar to transmembrane protein induced by tumor necrosis factor alpha ARHF 12q24.31 ras homolog gene family, member F (in filopodia) LOC338799 12q24.31 hypothetical protein LOC338799 KIAA1076 12q24.31 KIAA1076 protein HPD 12q24.1-q24.32 4-hydroxyphenylpyruvate dioxygenase PSMD9 12q24.31-q24.32 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 MGC33630 12q24.31 hypothetical protein MGC33630
    TRANSCRIPTS type messenger
    text several transcripts resulting from alternative polyadenylation and/or splicing of exons 14 and/or 16 (PMID: 11395482)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 initiation site 5620 64.6 588 - 2008 18436530
    also known as beta 1
    17 polyA site 2981 58.8 533 - 2008 18436530
  • also known as beta 2
  • containing an alternate segment in the 3' coding region and differing in the 3' UTR compared to variant 1
  • 16 splicing 5577 59.5 541 - 2008 18436530
  • also known as beta 1del16
  • lacking a segment in the coding region which leads to a frameshift compared to variant 1
  • encoding the same protein than variant 7
  • 16 splicing 5491 59.8 545 - 2008 18436530
  • also known as beta 1del14
  • lacking an in-frame segment of the coding region compared to variant 1
  • 15 - 5448 54.7 498 - 2008 18436530
  • also known as beta 1del14del16
  • having multiple differences in the coding region compared to variant 1, one of which results in a translational frameshift
  • 16 splicing 4923 59.5 541 - 2008 18436530
  • differing in the 5' UTR and also lacking a segment in the coding region, which leads to a frameshift compared to variant 1
  • encoding the same protein than variant 2
  • 16 splicing 2852 54 490 - 2008 18436530
  • also known as beta 2del14
  • differing in the 3' UTR and having multiple coding region differences compared to variant 1
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    Reproductivemale systemtestis   
     male systemprostate  highly
    Respiratoryrespiratory tractlarynx  highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose    Homo sapiens
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines in human non small cell lung cancers
    at STAGE
  • a catalytic domain
  • a regulatory region composed of an autoinhibitory domain
  • a CaM binding domain
  • AAs 129-151 participate in the release of the autoinhibitory domain from its catalytic core, resulting in generation of autonomous activity
  • a flag-tagged protein
    interspecies homolog to rattus Cmkkbeta
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CaMKK subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • serine/threonine protein kinase, calcium/calmodulin dependent
  • acting upstream of AMP-activated protein kinase in mammalian cells
  • has potentially a male-specific function in hippocampal memory formation and we have identified male-restricted transcription occurring during hippocampal memory formation
  • regulates hypothalamic production of the orexigenic hormone NPY and contributes to the regulation of energy balance
  • with STK11, catalyzing activation of PRKAB1 by phosphorylation at Thr172
  • act as regulatory enzymes for downstream protein kinases in various Ca2+-dependent cellular processes
  • mediates potentially novel Ca2+-signaling pathway(s), which are independent of downstream protein kinases
  • isoform-specific function for CAMKK2 that regulates ubiquitin signaling at the centrosome and thereby orchestrates dendrite patterning, with important implications for neuronal connectivity in the brain
  • role for CAMKK2 in the restriction of granulocytic fate commitment and differentiation of myeloid progenitor cells
  • CAMKK2 and PRKAB1 function in a signaling pathway that participates in the regulation of adiposity
    a component
  • CAMKK2-PRKAB1 complex that can be specifically targeted by small molecule drugs to treat disease
    small molecule
  • activating CAMK1, CAMK4 when coexpressed in Jurkat T cells
  • PACSIN1 is a CAMKK substrate (first non-kinase substrate for CaMKK2)
  • CAMKK2 can form a complex with and activate PRKAB1
  • a novel role of GPR39 in enhancing tight junction assembly in intestinal epithelial cells (IECs) via phospholipase C-CAMKK2-AMPK pathways
  • cell & other
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
  • CaMKK2 null mice have increased adiposity and larger adipocytes than do wild-type mice, whereas energy balance is unchanged