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FLASH GENE
Symbol CADPS contributors: mct/npt/pgu - updated : 04-07-2012
HGNC name Ca++-dependent secretion activator
HGNC id 1426
Location 3p14.2      Physical location : 62.384.020 - 62.861.064
Synonym name
  • Ca2+-dependent activator protein for secretion
  • Ca2+-regulated cytoskeletal protein
  • calcium-dependent activator protein for secretion 1
    • Synonym symbol(s) CAPS, KIAA1121, CAPS1, CADPS1
    DNA
    TYPE functioning gene
    STRUCTURE 477.03 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D3S1547 -D3S3631 - PDHB PDHB - CADPS - D3S1287 - FHIT - D3S1261 - cen
    Authors GeneMap (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 5482 152.6 1353 - 2003 12659812
    28 - 5365 148.6 1314 - 2003 12659812
    27 - 5245 144 1274 - 2003 12659812
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, spleen, brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a core SNARE-binding domain in CADPS as corresponding to Munc13 homology domain-1 (MHD1)
    • HOMOLOGY
    Homologene
    FAMILY CAPS family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • localized in the cell soma
    • basic FUNCTION
  • ca2+ dependent activator protein for secretion, neural/endocrine specific cytosolic required for the exocytosis of secretory vesicles, phopholipid protein, specifically interacting with phosphotidylinositol 4,5 biphosphate
  • conserved calcium binding protein essential for late-stage exocytosis of neurotransmitters from synaptic terminals
  • plays critical roles not only in Ca(2+)-dependent, regulated exocytosis but also in constitutive exocytosis downstream of vesicle docking
  • essential regulator of synaptic vesicle and large dense core vesicle priming in mammalian neurons and neuroendocrine cells
  • CADPs and CADPS2 promote monoamine uptake and storage mediated by the vesicular monoamine transporters SLC18A1 and SLC18A2
  • functions in priming Ca(2+)-dependent vesicle exocytosis
  • required for optimal vesicle exocytosis in neurons and endocrine cells where it functions to prime the exocytic machinery for Ca(2+)-triggered fusion
  • somal CADPS plays an important role in DCV (dense-core vesicles) trafficking in the trans-Golgi network (
  • functional role in the soma, a major subcellular localization site of CADPS in many cell types, in regulating DCV trafficking in the trans-Golgi network, via protein-protein interaction with ARF4/ARF5 in a GDP-dependent manner
  • regulates the exocytosis of catecholamine-containing or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites such as nerve terminals
  • possible involvement of somal CAPDS1 in DCV trafficking in the trans-Golgi network
  • . exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
  • although CADPS and UNC13A play crucial roles in the priming stage of secretion, their functions are non-redundant
  • novel mode of binding between CAPS1 and syntaxin-1, which play a crucial role in neurosecretion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction was confirmed for both the long and short isoforms of the D2 receptor, but not with any other dopamine receptor subtype
  • SNARE complex formation promoted by CADPS may be mediated by direct interactions of CADPS with each of the three SNARE proteins required for vesicle exocytosis
  • binds SNARE proteins and stimulates SNARE complex formation on liposomes, and SNARE protein binding is essential for CADPS function in dense-core vesicle exocytosis
  • CADPS binds to syntaxin-1 in a distinct mode from UNC13A
    • cell & other
    REGULATION
    Phosphorylated by by protein kinase CSNK2B that is required for CADPS activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CAPS2(-/-) and CAPS1(+/-), CAPS2(-/-) mice, despite having increased insulin sensitivity, are glucose intolerant and that this effect is attributable to a marked reduction of glucose-induced insulin secretion