Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol C7 contributors: mct - updated : 15-01-2007
HGNC name complement component 7
HGNC id 1346
Corresponding disease
C7D complement component 7 deficiency
Location 5p13      Physical location : 40.909.598 - 40.983.039
Synonym name complement component 7,beta-2 globulin
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation, tail to tail
text tail to tail with C6
STRUCTURE 73.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrineadrenal gland   predominantly
Hearing/Equilibriumearinnercochlea  
Lymphoid/Immunethymus   highly
Nervousnerve    
Reproductivefemale systemovary   
Respiratoryrespiratory tracttrachea  highly
Urinarybladder    
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two short consensus repeats, sushi structure (see F13B, SRCP1)
  • a perforin domain
  • two TSP type-1 domains
  • a MACPF domain
  • an EGF-like domain
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine C7
    Homologene
    FAMILY complement C6/C7/C8/C9 family
    CATEGORY immunity/defense , secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text located in the Golgi apparatus (Rameix-Welti 2007)
    basic FUNCTION
  • stable insertion of the C5b, C6, C7 complex into the cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with other late components of the cascade to form the membrane attack complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C5b, the C345C domain of C5 and the FIMs of C7, which mediates reversible binding of C5 to C7 in solution, plays an essential role in MAC (membrane attack complex) formation and complement lytic activity
  • C6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C7D
    related resource C7base - Mutation registry for C7 deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS