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FLASH GENE
Symbol C7 contributors: mct - updated : 15-01-2007
HGNC name complement component 7
HGNC id 1346
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two short consensus repeats, sushi structure (see F13B, SRCP1)
  • a perforin domain
  • two TSP type-1 domains
  • a MACPF domain
  • an EGF-like domain
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine C7
    Homologene
    FAMILY complement C6/C7/C8/C9 family
    CATEGORY immunity/defense , secretory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text located in the Golgi apparatus (Rameix-Welti 2007)
    basic FUNCTION
  • stable insertion of the C5b, C6, C7 complex into the cell membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with other late components of the cascade to form the membrane attack complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C5b, the C345C domain of C5 and the FIMs of C7, which mediates reversible binding of C5 to C7 in solution, plays an essential role in MAC (membrane attack complex) formation and complement lytic activity
  • C6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C7D
    related resource C7base - Mutation registry for C7 deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS