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FLASH GENE

Symbol

BZRAP1

contributors: mct/np - updated : 08-07-2015

HGNC name	benzodiazapine receptor (peripheral) associated protein 1
HGNC id	16831

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q22      Physical location : 56.378.595 - 56.406.152
Synonym name	cDNA sequence, expressed in brain, >100kDa, related to KIAA0318
	peripheral benzodiazepine receptor-associated protein 1
	RIMS-binding protein 1
Synonym symbol(s)	PRAX1, PRAX-1, KIAA0612, RIM-BP1, RIMBP1, RBP1, DKFZp686F02123, PBR-IP,

DNA

TYPE	functioning gene
STRUCTURE	27.57 kb     32 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004758 32 - 7706 NP_004749 - 1857 - 2007 17855024 NM_024418 31 - 7526 NP_077729 - 1797 - 2007 17855024 NM_001261835 32 - 7671 NP_001248764 - 1848 - 2007 17855024

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         endocrine brain diencephalon pituitary     Nervous nerve       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor Visual ganglion cell Visual rod photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	several domains involved in protein-protein interaction
	three proline-rich domains, partially involved in colocalization in the mitochondria, and required for the interaction with PBR (benzodiazepine receptor)
	three leucine zipper motifs
	three Src homology region 3 (SH3)-like domain, probably recognizing specific PXXP motifs
	two to three fibronectin III repeats (Mittelstaedt 2007)

HOMOLOGY

intraspecies

homolog to KIAA0318

Homologene

FAMILY

RIM-BP gene family

CATEGORY

adaptor , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
text	occur postsynaptically in dendrites and cell bodies

basic FUNCTION	may be functioning as a scaffold for the association between RIMS1, RIMS2, RIMS3, RIMS4 and voltage-gated Ca2+ channels
	having a potential role as important molecular adaptors (Mittelstaedt 2007)
	adaptor molecule known to regulate synaptic transmission (pMID: 19557195)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	peripheral benzodiazepine receptor (PBR)
	interacts with RIMS1 and RIMS2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS