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FLASH GENE
Symbol BZRAP1 contributors: mct/np - updated : 08-07-2015
HGNC name benzodiazapine receptor (peripheral) associated protein 1
HGNC id 16831
Location 17q22      Physical location : 56.378.595 - 56.406.152
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, related to KIAA0318
  • peripheral benzodiazepine receptor-associated protein 1
  • RIMS-binding protein 1
  • Synonym symbol(s) PRAX1, PRAX-1, KIAA0612, RIM-BP1, RIMBP1, RBP1, DKFZp686F02123, PBR-IP,
    DNA
    TYPE functioning gene
    STRUCTURE 27.57 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    32 - 7706 - 1857 - 2007 17855024
    31 - 7526 - 1797 - 2007 17855024
    32 - 7671 - 1848 - 2007 17855024
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    endocrinebraindiencephalonpituitary  
    Nervousnerve   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Visualcone photoreceptor
    Visualganglion cell
    Visualrod photoreceptor
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • several domains involved in protein-protein interaction
  • three proline-rich domains, partially involved in colocalization in the mitochondria, and required for the interaction with PBR (benzodiazepine receptor)
  • three leucine zipper motifs
  • three Src homology region 3 (SH3)-like domain, probably recognizing specific PXXP motifs
  • two to three fibronectin III repeats (Mittelstaedt 2007)
  • HOMOLOGY
    intraspecies homolog to KIAA0318
    Homologene
    FAMILY
  • RIM-BP gene family
  • CATEGORY adaptor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text occur postsynaptically in dendrites and cell bodies
    basic FUNCTION
  • may be functioning as a scaffold for the association between RIMS1, RIMS2, RIMS3, RIMS4 and voltage-gated Ca2+ channels
  • having a potential role as important molecular adaptors (Mittelstaedt 2007)
  • adaptor molecule known to regulate synaptic transmission (pMID: 19557195)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • peripheral benzodiazepine receptor (PBR)
  • interacts with RIMS1 and RIMS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS