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FLASH GENE
Symbol BZRAP1 contributors: mct/np - updated : 08-07-2015
HGNC name benzodiazapine receptor (peripheral) associated protein 1
HGNC id 16831
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several domains involved in protein-protein interaction
  • three proline-rich domains, partially involved in colocalization in the mitochondria, and required for the interaction with PBR (benzodiazepine receptor)
  • three leucine zipper motifs
  • three Src homology region 3 (SH3)-like domain, probably recognizing specific PXXP motifs
  • two to three fibronectin III repeats (Mittelstaedt 2007)
    • HOMOLOGY
    intraspecies homolog to KIAA0318
    Homologene
    FAMILY
  • RIM-BP gene family
    • CATEGORY adaptor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text occur postsynaptically in dendrites and cell bodies
    basic FUNCTION
  • may be functioning as a scaffold for the association between RIMS1, RIMS2, RIMS3, RIMS4 and voltage-gated Ca2+ channels
  • having a potential role as important molecular adaptors (Mittelstaedt 2007)
  • adaptor molecule known to regulate synaptic transmission (pMID: 19557195)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • peripheral benzodiazepine receptor (PBR)
  • interacts with RIMS1 and RIMS2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS