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FLASH GENE
Symbol BUB3 contributors: mct - updated : 08-10-2010
HGNC name BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
HGNC id 1151
Location 10q26.13      Physical location : 124.913.759 - 124.924.886
Synonym name
  • mitotic checkpoint component
  • kinetochore-associated checkpoint kinase 3
  • budding uninhibited by benomyl
  • Synonym symbol(s) BUB3L
    DNA
    TYPE functioning gene
    STRUCTURE 11.13 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    motif repetitive sequence   other
    text structure
  • The four WD repeat sequences localized to exons 2, 4, and 6, and a major transcriptional start site located 554 nucleotides upstream of the ATG translation initiator codon.
  • promoter with potential binding sites for the transcriptional factors including SP1, E2F, c-Myc, C/EBP and NFkappaB.
  • MAPPING cloned Y linked N status provisional
    Physical map
    FGFR2 10q26 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) ATE1 10q26.13 arginyltransferase 1 FLJ20003 10q26.13 hypothetical protein FLJ20003 TACC2 10q26 transforming, acidic coiled-coil containing protein 2 FLJ25359 10q26.13 hypothetical protein FLJ25359 PLEKHA1 10q26.3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 LOC387715 10 LOC387715 PRSS11 10q25.3-q26.2 protease, serine, 11 (IGF binding) LOC253436 10q26.13 hypothetical LOC253436 LOC390008 10 similar to hensin CUZD1 10q26.13 CUB and zona pellucida-like domains 1 MGC45962 10q26.13 hypothetical protein MGC45962 LOC118670 10q26.13 similar to hypothetical protein MGC45962 FLJ13490 10q26.13 hypothetical protein FLJ13490 MGC35392 10q26.13 hypothetical protein MGC35392 PEGASUS 10q26 zinc finger protein, subfamily 1A, 5 (Pegasus) ACADSB 10q25-q26 acyl-Coenzyme A dehydrogenase, short/branched chain LOC340784 10q26.13 similar to NK-type homeobox LOC387716 10 similar to Hmx2 protein LOC387717 10 LOC387717 BUB3 10q26 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) LOC390009 10 similar to 40S ribosomal protein S26 GPR26 10q26.2-q26.3 G protein-coupled receptor 26 DKFZp761H2121 10q26.13 hypothetical protein DKFZp761H2121 LOC119587 10q26.13 hypothetical protein LOC119587 GALNAC4S-6ST 10q26 hypothetical protein LOC119587 FLJ12616  hypothetical protein FLJ12616 LOC340735 10q26.2 similar to germ cell specific Y-box binding protein; contrin OAT 10q26 ornithine aminotransferase (gyrate atrophy) OATL3 10q26 ornithine aminotransferase-like 3 (pseudogene) LOC390010 10 similar to Sax-1 LHPP 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0140 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase KIAA0157 10q26.2 phospholysine phosphohistidine inorganic pyrophosphate phosphatase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2782 37 328 - 2002 12242018
    8 - 1555 36.8 326 - 2002 12242018
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
     mouth   highly
     pharynx   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G2M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four(? or five) WD repeats
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Bub1p
    Homologene
    FAMILY
  • WD repeat BUB3 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • mitotic spindle assembly checkpoint gene
  • modulating the timing of anaphase initiation in mitotic cells with improperly aligned chromosomes
  • promotes the formation of stable end-on bipolar attachments
  • required for regulation of both meiosis I and II, and is potentially involved in kinetochore-microtubule attachment in mammalian oocytes
  • together with BUB1, has a specific function in promoting the conversion from chromosome mono-orientation to bi-orientation
  • mediator protein inducing caspase-independent mitotic death in response to kinetochore–microtubule attachment defects
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing and recruiting to the kinetochore with BUB1 or BUB1B anaphase promoting complex
  • member of the SAC complex (spindle assembly checkpoint)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BUB1 or BUB1B
  • linking DYNLT3
  • interacting with TP73 (has a role in regulating SAC functions during meiosis and mitosis)
  • BUB1 interactor and a spindle checkpoint protein
  • interacts with TP73 specifically in cells in which CIMD (caspase-independent mitotic death) occurs
  • cell & other
    REGULATION
    inhibited by budding uninhibited by benzidimidazoles
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in glioblastoma
    constitutional     --over  
    affected the attachments of microtubules and kinetochores during metaphase-anaphase transition
    constitutional     --over  
    overexpression induces caspase-independent mitotic death (CIMD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS