basic FUNCTION
| mitotic spindle assembly checkpoint gene |
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modulating the timing of anaphase initiation in mitotic cells with improperly aligned chromosomes |
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promotes the formation of stable end-on bipolar attachments |
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required for regulation of both meiosis I and II, and is potentially involved in kinetochore-microtubule attachment in mammalian oocytes |
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together with BUB1, has a specific function in promoting the conversion from chromosome mono-orientation to bi-orientation |
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mediator protein inducing caspase-independent mitotic death in response to kinetochore–microtubule attachment defects |