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FLASH GENE
Symbol BTN2A1 contributors: mct - updated : 16-06-2008
HGNC name butyrophilin, subfamily 2, member A1
HGNC id 1136
Location 6p22.1      Physical location : 26.458.188 - 26.469.865
Synonym symbol(s) BTN2, BTN2A, BT2.1, BTF1, DJ3E1.1, BK14H9.1, FLJ36567
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily
STRUCTURE 11.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D6S1660 - D6S461 - D6S1691 - BTN2A1 - D6S464 - D6S1558 - cen
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2906 - 527 - Ruddy, Malcherek (2007)
8 splicing 3129 - 334 - Ruddy, Malcherek (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chicken B group B-G Ig-like domain (IgV-IgC1)
  • a transmembrane segment a large B30-2
  • C terminal domain
  • a signal sequence,and two short exons (7 and 9 AA)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • butyrophilin subfamily 2
  • B box family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION involved in cell proliferation and development
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein ligand for CD209 (tumor- or tissue-specific glycosylation of BTN2A1 governing recognition by CD209 on immature monocyte-derived dendritic cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS