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FLASH GENE
Symbol BTN2A1 contributors: mct - updated : 16-06-2008
HGNC name butyrophilin, subfamily 2, member A1
HGNC id 1136
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily
STRUCTURE 11.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D6S1660 - D6S461 - D6S1691 - BTN2A1 - D6S464 - D6S1558 - cen
Authors Gene Map (98)
Physical map
HIST1H4G 6p21.3 histone 1, H4g HIST1H3F 6p21.3 histone 1, H3f HIST1H2BH 6p21.3 histone 1, H2bh HIST1H3G 6p21.3 histone 1, H3g HIST1H2APS4 6p21.3 histone 1, H2a, pseudogene 4 HIST1H2BI 6p21.3 histone 1, H2bi HIST1H4H 6p21.3 histone 1, H4h BTN3A2 6p22.1 butyrophilin, subfamily 3, member A2 BTN2A2 6p22.1 butyrophilin, subfamily 2, member A2 BTN3A1 6p22.1 butyrophilin, subfamily 3, member A1 BTN2A3 6p22.1 butyrophilin, subfamily 2, member A3 BTN3A3 6p22.1 butyrophilin, subfamily 3, member A3 BTN2A1 6p22.1 butyrophilin, subfamily 2, member A1 BTN1A1 6p22.1 butyrophilin, subfamily 1, member A1 HMGN4 6p21.3 high mobility group nucleosomal binding domain 4
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2906 - 527 - Ruddy, Malcherek (2007)
8 splicing 3129 - 334 - Ruddy, Malcherek (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Nervousnerve   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chicken B group B-G Ig-like domain (IgV-IgC1)
  • a transmembrane segment a large B30-2
  • C terminal domain
  • a signal sequence,and two short exons (7 and 9 AA)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • butyrophilin subfamily 2
  • B box family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION involved in cell proliferation and development
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein ligand for CD209 (tumor- or tissue-specific glycosylation of BTN2A1 governing recognition by CD209 on immature monocyte-derived dendritic cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS