| basic FUNCTION
| non receptor tyrosine kinase |
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coupling activated immunoreceptors to downstream signaling events |
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playing crucial roles in the differentiation and activation of B and myeloid cells |
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having negative regulatory functions in dendritic cells, mediated mainly through autocrine secretion of IL10 and subsequent activation of STAT3 |
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required for NFkappaB activation, participating in the pathway to increased phosphorylation of RELA on serine 536 activated by TLR8 and TLR9  |
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is required for the initial loss of tolerance to DNA and the subsequent production of pathogenic autoantibodies once tolerance is breached |
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plays a central role in signal transduction pathways regulating survival, activation, proliferation, and differentiation of B-lineage lymphoid cells |
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BTK signaling is crucial for optimal actin cytoskeletal organization and lacunar resorption in isolated osteoclasts |
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essential for B cell development and function and also appears to be important for myeloid cells |
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important regulator of neutrophilic granulocyte maturation and function |
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positive regulator in the ITAM-mediated TREM1/TYROBP pathway, suggesting its implication in inflammatory processes |
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is essential for B-lymphocyte development |
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is not only critical for B cell development and differentiation but is also involved in the regulation of Toll-like receptor-triggered innate response of macrophages |
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is required for activation of NK cells, thus providing insight into the physiological significance of BTK in the regulation of immune cell functions and innate inflammatory response |
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BTK-induced activating phosphorylation is critical for the optimal transcription factor function of IKZF1 ( |
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BTK regulates dendritic cell responses upon TLR9 engagement in terms of activation, cytokine production, and STAT1/3 upregulation |
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not only plays a fundamental role in the regulation of BCR signalling, but may also mediate crosstalk with cytokine signalling pathways through regulation of IL21-induced phosphorylation of STAT1 in the nuclei of human B cells |
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BTK is an essential component of the NLRP3 inflammasome, in which BTK physically interacts with ASC and NLRP3 |
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mediates B cell signaling and is also present in innate immune cells but not T cells |
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contributions of BTK to immune tolerance |
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is a cytoplasmic protein tyrosine kinase with a fundamental role in B-lymphocyte development and activation |
