Citations for
1ANKRD54, BTK
ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library.
Gustafsson MO, Mohammad DK, Ylösmäki E, Choi H, Shrestha S, Wang Q, Nore BF, Saksela K, Smith CI.
PLoS One 12(4):e0174909. doi: 10.1371/journal.pone.0174909. eCollection 2017. 2017
2BTK
The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.
Crofford LJ, Nyhoff LE, Sheehan JH, Kendall PL.
Expert Rev Clin Immunol 12(7):763-73. doi: 10.1586/1744666X.2016.1152888. Epub 2016 Mar 4. Review. 2016
3BTK, NLRP3
Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.
Nat Commun 6:7360. doi: 10.1038/ncomms8360. 2015
4BTK
Amplification of IL-21 signalling pathway through Bruton's tyrosine kinase in human B cell activation.
Wang SP, Iwata S, Nakayamada S, Niiro H, Jabbarzadeh-Tabrizi S, Kondo M, Kubo S, Yoshikawa M, Tanaka Y.
Rheumatology (Oxford) 54(8):1488-97. doi: 10.1093/rheumatology/keu532. Epub 2015 Feb 26. 2015
5BTK
Bruton's tyrosine kinase (Btk) is a useful marker for Hodgkin and B cell non-Hodgkin lymphoma.
Fernández-Vega I, Quirós LM, Santos-Juanes J, Pane-Foix M, Marafioti T.
Virchows Arch 466(2):229-35. doi: 10.1007/s00428-014-1698-z. Epub 2014 Nov 30. 2015
6BTK, MAL, PRKCD
Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106.
Paracha RZ, Ali A, Ahmad J, Hussain R, Niazi U, Muhammad SA.
Comput Biol Chem 51:22-35. doi: 10.1016/j.compbiolchem.2014.04.001. Epub 2014 Apr 20. 2014
7BTK, TLR9
Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation.
Lougaris V, Baronio M, Vitali M, Tampella G, Cattalini M, Tassone L, Soresina A, Badolato R, Plebani A.
J Allergy Clin Immunol 133(6):1644-50.e4. doi: 10.1016/j.jaci.2013.12.1085. Epub 2014 Mar 4. 2014
8BTK
Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.
Rushworth SA, Murray MY, Zaitseva L, Bowles KM, MacEwan DJ.
Blood 123(8):1229-38. doi: 10.1182/blood-2013-06-511154. Epub 2013 Dec 4. 2014
9BTK, TLR7, TLR9
Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells.
Wang J, Lau KY, Jung J, Ravindran P, Barrat FJ.
Eur J Immunol 44(4):1130-6. doi: 10.1002/eji.201344030. Epub 2014 Jan 20. 2014
10BTK, IKZF1
Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase.
Ma H, Qazi S, Ozer Z, Zhang J, Ishkhanian R, Uckun FM.
PLoS One 8(8):e71302. doi: 10.1371/journal.pone.0071302. eCollection 2013. 2013
11ANKRD54, BTK, TXK
Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).
Gustafsson MO, Hussain A, Mohammad DK, Mohamed AJ, Nguyen V, Metalnikov P, Colwill K, Pawson T, Smith CI, Nore BF.
Mol Cell Biol 32(13):2440-53. doi: 10.1128/MCB.06620-11. Epub 2012 Apr 23. 2012
12BTK
Tyrosine kinase Btk is required for NK cell activation.
Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, Lau YL, Tu W, Cao X.
J Biol Chem 287(28):23769-78. doi: 10.1074/jbc.M112.372425. Epub 2012 May 15. 2012
13BTK
Tyrosine kinase Btk is required for NK cell activation.
Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, Lau YL, Tu W, Cao X.
J Biol Chem 287(28):23769-78. doi: 10.1074/jbc.M112.372425. Epub 2012 May 15. 2012
14BTK
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.
Herman SE, Gordon AL, Hertlein E, Ramanunni A, Zhang X, Jaglowski S, Flynn J, Jones J, Blum KA, Buggy JJ, Hamdy A, Johnson AJ, Byrd JC.
Blood 117(23):6287-96. Epub 2011 Mar 21. 2011
15BTK
Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia.
Fiedler K, Sindrilaru A, Terszowski G, Kokai E, Feyerabend TB, Bullinger L, Rodewald HR, Brunner C.
Blood 117(4):1329-39. Epub 2010 Nov 9. 2011
16BTK
Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts.
Danks L, Workman S, Webster D, Horwood NJ.
J Bone Miner Res 26(1):182-92. 2011
17BTK, KAT2A, SYK
GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.
Kikuchi H, Kuribayashi F, Takami Y, Imajoh-Ohmi S, Nakayama T.
Biochem Biophys Res Commun 405(4):657-61. Epub 2011 Jan 31. 2011
18AGMX1, BTK
Clinical characteristics and molecular analysis of 21 Chinese children with congenital agammaglobulinemia.
Zhang ZY, Zhao XD, Jiang LP, Liu EM, Wang M, Yu J, Liu P, Yang XQ.
Scand J Immunol 72(5):454-9. doi: 10.1111/j.1365-3083.2010.02457.x. 2010
19BTK
Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
Marcotte DJ, Liu YT, Arduini RM, Hession CA, Miatkowski K, Wildes CP, Cullen PF, Hong V, Hopkins BT, Mertsching E, Jenkins TJ, Romanowski MJ, Baker DP, Silvian LF.
Protein Sci 19(3):429-39. 2010
20BTK
Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity.
Lin L, Czerwinski R, Kelleher K, Siegel MM, Wu P, Kriz R, Aulabaugh A, Stahl M.
Biochemistry 48(9):2021-32.PMID: 19206206 2009
21BTK, CDC73
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT.
Sci Signal 2(72):ra25. 2009
22ARID3A, BTK, GTF2I
Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.
Schmidt C, Kim D, Ippolito GC, Naqvi HR, Probst L, Mathur S, Rosas-Acosta G, Wilson VG, Oldham AL, Poenie M, Webb CF, Tucker PW.
EMBO J 28(6):711-24. Epub 2009 Feb 12. 2009
23BTK
Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol.
Murayama K, Kato-Murayama M, Mishima C, Akasaka R, Shirouzu M, Fukui Y, Yokoyama S.
Biochem Biophys Res Commun 377(1):23-8. Epub 2008 Sep 20.PMID: 18809383 2008
24AGMX1, BTK
Genotype-phenotype correlation in Bruton's tyrosine kinase deficiency.
Teimourian S, Nasseri S, Pouladi N, Yeganeh M, Aghamohammadi A.
J Pediatr Hematol Oncol 30(9):679-83.PMID: 18776760 2008
25BTK
Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
Halcomb KE, Musuka S, Gutierrez T, Wright HL, Satterthwaite AB.
Mol Immunol 46(2):233-41. Epub 2008 Oct 11. 2008
26BTK, TLR8, TLR9
Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
Doyle SL, Jefferies CA, Feighery C, O'Neill LA.
J Biol Chem 282(51):36953-60. Epub 2007 Oct 11.PMID: 17932028 2007
27IL10, STAT3, BTK
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.
Kawakami Y, Inagaki N, Salek-Ardakani S, Kitaura J, Tanaka H, Nagao K, Kawakami Y, Xiao W, Nagai H, Croft M, Kawakami T.
Proc Natl Acad Sci U S A 103(1):153-8. Epub 2005 Dec 21. 2006
28AGMX1,BTK
BTKbase: the mutation database for X-linked agammaglobulinemia.
Valiaho J, Smith CI, Vihinen M.
Hum Mutat 27(12):1209-17. Review. 2006
29AGMX1, BTK
Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations.
Wattanasirichaigoon D, Benjaponpitak S, Techasaensiri C, Kamchaisatian W, Vichyanond P, Janwityanujit S, Choubtum L, Sirinavin S.
J Hum Genet 51(11):1006-14. Epub 2006 Sep 2. 2006
30BTK, TIRAP, TLR2, TLR4
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.
Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA.
J Biol Chem 281(15):10489-95. Epub 2006 Jan 26. 2006
31ARID3A, BTK, GTF2I
Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.
Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF.
Mol Cell Biol 26(12):4758-68. 2006
32AGMX1, BTK
Identification of mutations in the Bruton's tyrosine kinase gene, including a novel genomic rearrangements resulting in large deletion, in Korean X-linked agammaglobulinemia patients.
Jo EK, Wang Y, Kanegane H, Futatani T, Song CH, Park JK, Kim JS, Kim DS, Ahn KM, Lee SI, Park HJ, Hahn YS, Lee JH, Miyawaki T.
J Hum Genet 48(6):322-6. Epub 2003 May 24. 2003
33BLNK, BTK, SYK
BLNK mediates Syk-dependent Btk activation.
Baba Y, Hashimoto S, Matsushita M, Watanabe D, Kishimoto T, Kurosaki T, Tsukada S.
Proc Natl Acad Sci U S A 98(5):2582-6. 2001
34BTK, GD5S
The BTK gene as candidate gene for Graves'disease.
Villanueva RB, Barbesino G, Greenberg DA, Concepcion E, Tucci S, Davies TF, Tomer Y.
Gene Funct Dis 2 : 99-101. 2000
35AGMX1, BTK
Mutations of the human BTK gene coding for bruton tyrosine kinase in X-linked agammaglobulinemia.
Vihinen M, et al.
Hum Mutat 13 : 280-285. 1999
36AGMX1, BTK
Unusual mutations in Btk: an insertion, a duplication, an inversion, and four large deletions.
Rohrer J, et al.
Clin Immunol 90(1):28-37. 1999
37AGMX1, BTK
Mutations in Btk in patients with presumed X-linked agammaglobulinemia.
Conley ME, et al.
Am J Hum Genet 62 : 1034-1043. 1998
38AGMX1, BTK
Mutation pattern in the Bruton's tyrosine kinase gene in 26 unrelated patients with X-linked agammaglobulinemia.
Vorechovsky I, et al.
Hum Mutat 9 : 418-425. 1997
39BTK
Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains.
Oeltjen JC, et al.
Genome Res 7 : 315-329. 1997
40AGMX1, BTK
Unusual patterns of exon skipping in Bruton tyrosine kinase are associated with mutations involving the intron 17 3' splice site.
Haire RN, et al.
Am J Hum Genet 60 : 798-807. 1997
41AGMX1, BTK
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
Hyvonen M, Saraste M.
EMBO J 16(12):3396-404. 1997
42AGMX1, BTK
Identification of novel Bruton's tyrosine kinase mutations in 10 unrelated subjects with X linked agammaglobulinaemia.
Brooimans RA, van den Berg AJ, Rijkers GT, Sanders LA, van Amstel JK, Tilanus MG, Grubben MJ, Zegers BJ.
J Med Genet 34(6):484-8. 1997
43AGMX1, BTK
Discordant phenotype in siblings with X-linked agammaglobulinemia.
Bykowsky MJ, et al.
Am J Hum Genet 58 : 477-483. 1996
44BTK, AGMX1
Mutations of the Btk gene in 12 unrelated families with X-linked agammablobulinemia in Japan.
Kobayashi S, et al.
Hum Genet 97 : 424-430. 1996
45AGMX1, BTK
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity.
Fukuda M, et al.
J Biol Chem 271 : 30303-30306. 1996
46BTK, GAA, GSD2
Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci.
Oeltjen JC, et al.
Mamm Genome 6 : 334-338. 1995
47AGMX1, BTK
Mutation analysis of the gene encoding Bruton's tyrosine kinase in a family with a sporadic case of X-linked agammaglobulinemia reveals three female carriers.
Hagemann TL, et al.
Am J Med Genet 59 : 188-192. 1995
48AGMX1, BTK
Improved oligonucleotide primer set for molecular diagnosis of X-linked agammaglobulinaemia : predominance of amino acid substitutions in the catalytic domain of Bruton's tyrosine kinase.
Vorechovsky I, et al.
Hum Mol Genet 4 : 2403-2405. 1995
49AGMX1, BTK
Identification of Btk mutations in 20 unrelated patients with X-linked agammaglobulinaemia (XLA).
Jin H, et al.
Hum Mol Genet 4 : 693-700. 1995
50AGMX1, BTK
Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot.
Gaspar HB, et al.
Hum Mol Genet 4 : 755-757. 1995
51BTK, PRKCI
Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3.
Mazzarella R, et al.
Genomics 26 : 629-631. 1995
52AGMX1, BTK
DNA-based mutation analysis of Bruton's tyrosine kinase gene in patients with X-linked agammaglobulinaemia.
Vorechovsky I, et al.
Hum Mol Genet 4 : 51-58. 1995
53AGMX1, BTK
Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia : identification of a mutation which affects the same codon as is altered in immunodeficient xid mice.
De Weers M, et al.
Hum Mol Genet 3 : 161-166. 1994
54BTK, AGMX1, BTK
Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis.
Bradley LAD, et al.
Hum Mol Genet 3 : 79-83. 1994
55BTK
SSCP at the BTK locus.
Vorechovsky I.
Hum Mol Genet 3 : 1031. 1994
56BTK
Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22.
Vorechovsky I, et al.
Genomics 21 : 517-524. 1994
57BTK, AGMX1
Identification of deletions in the btk gene allows unambiguous assessment of carrier status in families with X-linked agammaglobulinaemia.
Lovering RC, et al.
Hum Genet 94 : 77-79. 1994
58AGMX1, BTK
Genomic organization and structure of Bruton agammaglobulinemia tyrosinekinase : localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia.
Ohta Y, et al.
Proc Natl Acad Sci U S A 91 : 9062-9066. 1994
59BTK, AGMX1
Unique mutations of Bruton's tyrosine kinase in fourteen unrelated X-linked agammaglobulinemia families. (abstr)
Zhu Q, et al.
Hum Mol Genet 3 : 1899-1900. 1994
60BTK, AGMX1
Screening of genomic DNA to identify mutations in the gene for Bruton's tyrosine kinase.
Conley ME, et al.
Hum Mol Genet 3 : 1751-1756. 1994
61BTK, AGMX1
Genomic organization of the Btk gene and exon scanning for mutations in patients with X-linked agammaglobulinemia.
Hagemann TL, et al.
Hum Mol Genet 3 : 1743-1749. 1994
62AGMX1, BTK
Physical mapping in the region of the Bruton's tyrosine kinase and alpha-galactosidase A gene loci in proximal Xq22.
Sweatman AK, et al.
Hum Genet 94 : 624-628. 1994
63BTK
Structural basis for chromosome X-linked agammaglobulinemia : a tyrosine kinase disease.
Vihinen M, et al.
Proc Natl Acad Sci U S A 91 : 12803-12807. 1994
64BTK,IGHD3
An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency.
Duriez B, Duquesnoy P, Dastot F, Bougneres P, Amselem S, Goossens M.
FEBS Lett 346(2-3):165-70. 1994
65BTK
A BstNI polymorphism at the BTK locus in Xq21.3-Xq22.
Hagemann T, et al.
Hum Mol Genet 2 : 2201. 1993
66BTK, AGMX1
Absence of xid mutation in X-linked agammaglobulinaemia.
Vorechovsky I, et al.
Lancet 342 : 552. 1993
67BTK, AGMX1
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.
Vetrie D, et al.
Nature 361 : 226-233. 1993
68BTK, AGMX1
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
Tsukada S, et al.
Cell 72 : 279-290. 1993
69AGMX1,BTK,IGHD3
Molecular analysis of X-linked agammaglobulinemia with growth hormone deficiency.
Conley ME, Burks AW, Herrod HG, Puck JM.
J Pediatr 119(3):392-7. 1991