| 1 | ANKRD54, BTK
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| ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library.
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| Gustafsson MO, Mohammad DK, Ylösmäki E, Choi H, Shrestha S, Wang Q, Nore BF, Saksela K, Smith CI.
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| PLoS One 12(4):e0174909. doi: 10.1371/journal.pone.0174909. eCollection 2017.
2017
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| 2 | BTK
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| The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy.
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| Crofford LJ, Nyhoff LE, Sheehan JH, Kendall PL.
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| Expert Rev Clin Immunol 12(7):763-73. doi: 10.1586/1744666X.2016.1152888. Epub 2016 Mar 4. Review.
2016
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| 3 | BTK, NLRP3
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| Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
|
| Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.
|
| Nat Commun 6:7360. doi: 10.1038/ncomms8360.
2015
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| 4 | BTK
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| Amplification of IL-21 signalling pathway through Bruton's tyrosine kinase in human B cell activation.
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| Wang SP, Iwata S, Nakayamada S, Niiro H, Jabbarzadeh-Tabrizi S, Kondo M, Kubo S, Yoshikawa M, Tanaka Y.
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| Rheumatology (Oxford) 54(8):1488-97. doi: 10.1093/rheumatology/keu532. Epub 2015 Feb 26.
2015
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| 5 | BTK
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| Bruton's tyrosine kinase (Btk) is a useful marker for Hodgkin and B cell non-Hodgkin lymphoma.
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| Fernández-Vega I, Quirós LM, Santos-Juanes J, Pane-Foix M, Marafioti T.
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| Virchows Arch 466(2):229-35. doi: 10.1007/s00428-014-1698-z. Epub 2014 Nov 30.
2015
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| 6 | BTK, MAL, PRKCD
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| Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106.
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| Paracha RZ, Ali A, Ahmad J, Hussain R, Niazi U, Muhammad SA.
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| Comput Biol Chem 51:22-35. doi: 10.1016/j.compbiolchem.2014.04.001. Epub 2014 Apr 20.
2014
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| 7 | BTK, TLR9
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| Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation.
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| Lougaris V, Baronio M, Vitali M, Tampella G, Cattalini M, Tassone L, Soresina A, Badolato R, Plebani A.
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| J Allergy Clin Immunol 133(6):1644-50.e4. doi: 10.1016/j.jaci.2013.12.1085. Epub 2014 Mar 4.
2014
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| 8 | BTK
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| Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.
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| Rushworth SA, Murray MY, Zaitseva L, Bowles KM, MacEwan DJ.
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| Blood 123(8):1229-38. doi: 10.1182/blood-2013-06-511154. Epub 2013 Dec 4.
2014
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| 9 | BTK, TLR7, TLR9
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| Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells.
|
| Wang J, Lau KY, Jung J, Ravindran P, Barrat FJ.
|
| Eur J Immunol 44(4):1130-6. doi: 10.1002/eji.201344030. Epub 2014 Jan 20.
2014
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| 10 | BTK, IKZF1
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| Regulatory phosphorylation of Ikaros by Bruton's tyrosine kinase.
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| Ma H, Qazi S, Ozer Z, Zhang J, Ishkhanian R, Uckun FM.
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| PLoS One 8(8):e71302. doi: 10.1371/journal.pone.0071302. eCollection 2013.
2013
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| 11 | ANKRD54, BTK, TXK
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| Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).
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| Gustafsson MO, Hussain A, Mohammad DK, Mohamed AJ, Nguyen V, Metalnikov P, Colwill K, Pawson T, Smith CI, Nore BF.
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| Mol Cell Biol 32(13):2440-53. doi: 10.1128/MCB.06620-11. Epub 2012 Apr 23.
2012
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| 12 | BTK
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| Tyrosine kinase Btk is required for NK cell activation.
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| Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, Lau YL, Tu W, Cao X.
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| J Biol Chem 287(28):23769-78. doi: 10.1074/jbc.M112.372425. Epub 2012 May 15.
2012
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| 13 | BTK
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| Tyrosine kinase Btk is required for NK cell activation.
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| Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, Lau YL, Tu W, Cao X.
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| J Biol Chem 287(28):23769-78. doi: 10.1074/jbc.M112.372425. Epub 2012 May 15.
2012
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| 14 | BTK
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| Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.
|
| Herman SE, Gordon AL, Hertlein E, Ramanunni A, Zhang X, Jaglowski S, Flynn J, Jones J, Blum KA, Buggy JJ, Hamdy A, Johnson AJ, Byrd JC.
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| Blood 117(23):6287-96. Epub 2011 Mar 21.
2011
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| 15 | BTK
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| Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia.
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| Fiedler K, Sindrilaru A, Terszowski G, Kokai E, Feyerabend TB, Bullinger L, Rodewald HR, Brunner C.
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| Blood 117(4):1329-39. Epub 2010 Nov 9.
2011
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| 16 | BTK
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| Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts.
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| Danks L, Workman S, Webster D, Horwood NJ.
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| J Bone Miner Res 26(1):182-92.
2011
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| 17 | BTK, KAT2A, SYK
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| GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.
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| Kikuchi H, Kuribayashi F, Takami Y, Imajoh-Ohmi S, Nakayama T.
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| Biochem Biophys Res Commun 405(4):657-61. Epub 2011 Jan 31.
2011
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| 18 | AGMX1, BTK
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| Clinical characteristics and molecular analysis of 21 Chinese children with congenital agammaglobulinemia.
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| Zhang ZY, Zhao XD, Jiang LP, Liu EM, Wang M, Yu J, Liu P, Yang XQ.
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| Scand J Immunol 72(5):454-9. doi: 10.1111/j.1365-3083.2010.02457.x.
2010
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| 19 | BTK
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| Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
|
| Marcotte DJ, Liu YT, Arduini RM, Hession CA, Miatkowski K, Wildes CP, Cullen PF, Hong V, Hopkins BT, Mertsching E, Jenkins TJ, Romanowski MJ, Baker DP, Silvian LF.
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| Protein Sci 19(3):429-39.
2010
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| 20 | BTK
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| Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity.
|
| Lin L, Czerwinski R, Kelleher K, Siegel MM, Wu P, Kriz R, Aulabaugh A, Stahl M.
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| Biochemistry 48(9):2021-32.PMID: 19206206 2009
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| 21 | BTK, CDC73
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| Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
|
| James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT.
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| Sci Signal 2(72):ra25.
2009
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| 22 | ARID3A, BTK, GTF2I
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| Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.
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| Schmidt C, Kim D, Ippolito GC, Naqvi HR, Probst L, Mathur S, Rosas-Acosta G, Wilson VG, Oldham AL, Poenie M, Webb CF, Tucker PW.
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| EMBO J 28(6):711-24. Epub 2009 Feb 12.
2009
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| 23 | BTK
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| Crystal structure of the Bruton's tyrosine kinase PH domain with phosphatidylinositol.
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| Murayama K, Kato-Murayama M, Mishima C, Akasaka R, Shirouzu M, Fukui Y, Yokoyama S.
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| Biochem Biophys Res Commun 377(1):23-8. Epub 2008 Sep 20.PMID: 18809383 2008
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| 24 | AGMX1, BTK
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| Genotype-phenotype correlation in Bruton's tyrosine kinase deficiency.
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| Teimourian S, Nasseri S, Pouladi N, Yeganeh M, Aghamohammadi A.
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| J Pediatr Hematol Oncol 30(9):679-83.PMID: 18776760 2008
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| 25 | BTK
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| Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells.
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| Halcomb KE, Musuka S, Gutierrez T, Wright HL, Satterthwaite AB.
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| Mol Immunol 46(2):233-41. Epub 2008 Oct 11.
2008
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| 26 | BTK, TLR8, TLR9
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| Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
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| Doyle SL, Jefferies CA, Feighery C, O'Neill LA.
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| J Biol Chem 282(51):36953-60. Epub 2007 Oct 11.PMID: 17932028 2007
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| 27 | IL10, STAT3, BTK
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| Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.
|
| Kawakami Y, Inagaki N, Salek-Ardakani S, Kitaura J, Tanaka H, Nagao K, Kawakami Y, Xiao W, Nagai H, Croft M, Kawakami T.
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| Proc Natl Acad Sci U S A 103(1):153-8. Epub 2005 Dec 21. 2006
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| 28 | AGMX1,BTK
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| BTKbase: the mutation database for X-linked agammaglobulinemia.
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| Valiaho J, Smith CI, Vihinen M.
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| Hum Mutat 27(12):1209-17. Review. 2006
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| 29 | AGMX1, BTK
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| Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations.
|
| Wattanasirichaigoon D, Benjaponpitak S, Techasaensiri C, Kamchaisatian W, Vichyanond P, Janwityanujit S, Choubtum L, Sirinavin S.
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| J Hum Genet 51(11):1006-14. Epub 2006 Sep 2.
2006
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| 30 | BTK, TIRAP, TLR2, TLR4
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| MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.
|
| Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA.
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| J Biol Chem 281(15):10489-95. Epub 2006 Jan 26.
2006
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| 31 | ARID3A, BTK, GTF2I
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| Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.
|
| Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF.
|
| Mol Cell Biol 26(12):4758-68.
2006
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| 32 | AGMX1, BTK
|
| Identification of mutations in the Bruton's tyrosine kinase gene, including a novel genomic rearrangements resulting in large deletion, in Korean X-linked agammaglobulinemia patients.
|
| Jo EK, Wang Y, Kanegane H, Futatani T, Song CH, Park JK, Kim JS, Kim DS, Ahn KM, Lee SI, Park HJ, Hahn YS, Lee JH, Miyawaki T.
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| J Hum Genet 48(6):322-6. Epub 2003 May 24. 2003
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| 33 | BLNK, BTK, SYK
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| BLNK mediates Syk-dependent Btk activation.
|
| Baba Y, Hashimoto S, Matsushita M, Watanabe D, Kishimoto T, Kurosaki T, Tsukada S.
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| Proc Natl Acad Sci U S A 98(5):2582-6. 2001
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| 34 | BTK, GD5S
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| The BTK gene as candidate gene for Graves'disease.
|
| Villanueva RB, Barbesino G, Greenberg DA, Concepcion E, Tucci S, Davies TF, Tomer Y.
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| Gene Funct Dis 2 : 99-101. 2000
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| 35 | AGMX1, BTK
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| Mutations of the human BTK gene coding for bruton tyrosine kinase in X-linked agammaglobulinemia.
|
| Vihinen M, et al.
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| Hum Mutat 13 : 280-285. 1999
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| 36 | AGMX1, BTK
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| Unusual mutations in Btk: an insertion, a duplication, an inversion, and four large deletions.
|
| Rohrer J, et al.
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| Clin Immunol 90(1):28-37. 1999
|
| 37 | AGMX1, BTK
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| Mutations in Btk in patients with presumed X-linked agammaglobulinemia.
|
| Conley ME, et al.
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| Am J Hum Genet 62 : 1034-1043. 1998
|
| 38 | AGMX1, BTK
|
| Mutation pattern in the Bruton's tyrosine kinase gene in 26 unrelated patients with X-linked agammaglobulinemia.
|
| Vorechovsky I, et al.
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| Hum Mutat 9 : 418-425. 1997
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| 39 | BTK
|
| Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains.
|
| Oeltjen JC, et al.
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| Genome Res 7 : 315-329. 1997
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| 40 | AGMX1, BTK
|
| Unusual patterns of exon skipping in Bruton tyrosine kinase are associated with mutations involving the intron 17 3' splice site.
|
| Haire RN, et al.
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| Am J Hum Genet 60 : 798-807. 1997
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| 41 | AGMX1, BTK
|
| Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
|
| Hyvonen M, Saraste M.
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| EMBO J 16(12):3396-404. 1997
|
| 42 | AGMX1, BTK
|
| Identification of novel Bruton's tyrosine kinase mutations in 10 unrelated subjects with X linked agammaglobulinaemia.
|
| Brooimans RA, van den Berg AJ, Rijkers GT, Sanders LA, van Amstel JK, Tilanus MG, Grubben MJ, Zegers BJ.
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| J Med Genet 34(6):484-8. 1997
|
| 43 | AGMX1, BTK
|
| Discordant phenotype in siblings with X-linked agammaglobulinemia.
|
| Bykowsky MJ, et al.
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| Am J Hum Genet 58 : 477-483. 1996
|
| 44 | BTK, AGMX1
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| Mutations of the Btk gene in 12 unrelated families with X-linked agammablobulinemia in Japan.
|
| Kobayashi S, et al.
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| Hum Genet 97 : 424-430. 1996
|
| 45 | AGMX1, BTK
|
| Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity.
|
| Fukuda M, et al.
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| J Biol Chem 271 : 30303-30306. 1996
|
| 46 | BTK, GAA, GSD2
|
| Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci.
|
| Oeltjen JC, et al.
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| Mamm Genome 6 : 334-338. 1995
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| 47 | AGMX1, BTK
|
| Mutation analysis of the gene encoding Bruton's tyrosine kinase in a family with a sporadic case of X-linked agammaglobulinemia reveals three female carriers.
|
| Hagemann TL, et al.
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| Am J Med Genet 59 : 188-192. 1995
|
| 48 | AGMX1, BTK
|
| Improved oligonucleotide primer set for molecular diagnosis of X-linked agammaglobulinaemia : predominance of amino acid substitutions in the catalytic domain of Bruton's tyrosine kinase.
|
| Vorechovsky I, et al.
|
| Hum Mol Genet 4 : 2403-2405. 1995
|
| 49 | AGMX1, BTK
|
| Identification of Btk mutations in 20 unrelated patients with X-linked agammaglobulinaemia (XLA).
|
| Jin H, et al.
|
| Hum Mol Genet 4 : 693-700. 1995
|
| 50 | AGMX1, BTK
|
| Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot.
|
| Gaspar HB, et al.
|
| Hum Mol Genet 4 : 755-757. 1995
|
| 51 | BTK, PRKCI
|
| Human protein kinase C iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3.
|
| Mazzarella R, et al.
|
| Genomics 26 : 629-631. 1995
|
| 52 | AGMX1, BTK
|
| DNA-based mutation analysis of Bruton's tyrosine kinase gene in patients with X-linked agammaglobulinaemia.
|
| Vorechovsky I, et al.
|
| Hum Mol Genet 4 : 51-58. 1995
|
| 53 | AGMX1, BTK
|
| Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia : identification of a mutation which affects the same codon as is altered in immunodeficient xid mice.
|
| De Weers M, et al.
|
| Hum Mol Genet 3 : 161-166. 1994
|
| 54 | BTK, AGMX1, BTK
|
| Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis.
|
| Bradley LAD, et al.
|
| Hum Mol Genet 3 : 79-83. 1994
|
| 55 | BTK
|
| SSCP at the BTK locus.
|
| Vorechovsky I.
|
| Hum Mol Genet 3 : 1031. 1994
|
| 56 | BTK
|
| Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22.
|
| Vorechovsky I, et al.
|
| Genomics 21 : 517-524. 1994
|
| 57 | BTK, AGMX1
|
| Identification of deletions in the btk gene allows unambiguous assessment of carrier status in families with X-linked agammaglobulinaemia.
|
| Lovering RC, et al.
|
| Hum Genet 94 : 77-79. 1994
|
| 58 | AGMX1, BTK
|
| Genomic organization and structure of Bruton agammaglobulinemia tyrosinekinase : localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia.
|
| Ohta Y, et al.
|
| Proc Natl Acad Sci U S A 91 : 9062-9066. 1994
|
| 59 | BTK, AGMX1
|
| Unique mutations of Bruton's tyrosine kinase in fourteen unrelated X-linked agammaglobulinemia families. (abstr)
|
| Zhu Q, et al.
|
| Hum Mol Genet 3 : 1899-1900. 1994
|
| 60 | BTK, AGMX1
|
| Screening of genomic DNA to identify mutations in the gene for Bruton's tyrosine kinase.
|
| Conley ME, et al.
|
| Hum Mol Genet 3 : 1751-1756. 1994
|
| 61 | BTK, AGMX1
|
| Genomic organization of the Btk gene and exon scanning for mutations in patients with X-linked agammaglobulinemia.
|
| Hagemann TL, et al.
|
| Hum Mol Genet 3 : 1743-1749. 1994
|
| 62 | AGMX1, BTK
|
| Physical mapping in the region of the Bruton's tyrosine kinase and alpha-galactosidase A gene loci in proximal Xq22.
|
| Sweatman AK, et al.
|
| Hum Genet 94 : 624-628. 1994
|
| 63 | BTK
|
| Structural basis for chromosome X-linked agammaglobulinemia : a tyrosine kinase disease.
|
| Vihinen M, et al.
|
| Proc Natl Acad Sci U S A 91 : 12803-12807. 1994
|
| 64 | BTK,IGHD3
|
| An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency.
|
| Duriez B, Duquesnoy P, Dastot F, Bougneres P, Amselem S, Goossens M.
|
| FEBS Lett 346(2-3):165-70. 1994
|
| 65 | BTK
|
| A BstNI polymorphism at the BTK locus in Xq21.3-Xq22.
|
| Hagemann T, et al.
|
| Hum Mol Genet 2 : 2201. 1993
|
| 66 | BTK, AGMX1
|
| Absence of xid mutation in X-linked agammaglobulinaemia.
|
| Vorechovsky I, et al.
|
| Lancet 342 : 552. 1993
|
| 67 | BTK, AGMX1
|
| The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.
|
| Vetrie D, et al.
|
| Nature 361 : 226-233. 1993
|
| 68 | BTK, AGMX1
|
| Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
|
| Tsukada S, et al.
|
| Cell 72 : 279-290. 1993
|
| 69 | AGMX1,BTK,IGHD3
|
| Molecular analysis of X-linked agammaglobulinemia with growth hormone deficiency.
|
| Conley ME, Burks AW, Herrod HG, Puck JM.
|
| J Pediatr 119(3):392-7. 1991
|