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FLASH GENE
Symbol BEX2 contributors: mct/npt - updated : 29-09-2007
HGNC name brain expressed X-linked 2
HGNC id 30933
Location Xq22      Physical location : 102.564.281 - 102.565.974
Synonym name brain expressed, X-linked 1 protein
Synonym symbol(s) BEX1, DJ79P11.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text BEX2 and its homologue BEX1 have highly correlated expression and are part of a cluster enriched for ER response and apoptosis genes
STRUCTURE 1.67 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 878 - 128 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
 pancreas    
Nervousbraindiencephalonhypothalamus  
 brainforebraincerebral lobefrontal 
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text highly in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Bex2
intraspecies paralog to BEX1
Homologene
FAMILY
  • BEX family
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be a signaling adaptor molecule
  • can enhance the transcriptional activity of LMO2
  • may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains BEX2, LMO2, NSCL2 and LDB1
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a DNA-binding protein complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LMO2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of primary breast cancers, mediating nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines (Naderi 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS