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FLASH GENE
Symbol BEX2 contributors: mct/npt - updated : 20-03-2018
HGNC name brain expressed X-linked 2
HGNC id 30933
Location Xq22.2      Physical location : 102.564.281 - 102.565.974
Synonym name brain expressed, X-linked 1 protein
Synonym symbol(s) BEX1, DJ79P11.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text BEX2 and its homologue BEX1 have highly correlated expression and are part of a cluster enriched for ER response and apoptosis genes
STRUCTURE 1.70 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 878 - 128 - 2012 23022184
3 - 842 - 128 - 2012 23022184
3 - 1097 - 159 - 2012 23022184
3 - 1100 - 160 - 2012 23022184
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
 neuroendocrinepituitary  highly Homo sapiens
Nervousbraindiencephalonhypothalamus  Homo sapiens
 brainforebraincerebral lobetemporal lobehighly Homo sapiens
 brainhindbraincerebellum highly Homo sapiens
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text highly in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Bex2
intraspecies paralog to BEX1
Homologene
FAMILY
  • Brain Expressed X-linked gene family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be a signaling adaptor molecule
  • can enhance the transcriptional activity of LMO2
  • may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains BEX2, LM2, NSCL2 and LDB1
  • is implicated in oligodendroglioma biology
  • has a functional interplay with JUN/JNK and RELA in breast cancer
  • may be an important player during the development of glioma
  • contributes to glioma development by regulating the JUN NH2-terminal kinase pathway
  • regulates the invasion/migration ability of glioma cells
  • increased BEX2 expression led to enhanced NFKB1 signaling as well as cell proliferation
  • while BEX1 and NGFRAP1 act as tumor suppressors, BEX2 seems to act as an oncogene
  • BEX2 promotes colorectal cancer cell proliferation via the JNK/JUN pathway
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a DNA-binding protein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LMO2
  • BEX2 promoted the progression of glioma by promoting cell migration and invasion, and these effects might be mediated by CDH2 and MMP2
  • BEX2 promotes proliferation of human glioblastoma cells via NFKB1 signaling pathway and BEX2 nuclear location is critical for RELA expression
  • BEX2 affects the invasion and migration ability of glioma cells by regulating CTNNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of primary breast cancers, mediating nerve growth factor/nuclear factor-kappaB inhibition of apoptosis in breast cancer cell lines (Naderi 2007)
    tumoral     --over  
    in glioma tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    contributes to glioma development by regulating the JUN NH2-terminal kinase pathway
    cancerdigestivecolon
    BEX2 as a potential candidate target for the treatment of colorectal cancer (CRC)
    cancerbrain 
    potential target for novel therapies for ependymoma in children
    ANIMAL & CELL MODELS
  • Bex2-deficient mice were viable and fertile under laboratory growth conditions showing no obvious phenotypic abnormalities 3)