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FLASH GENE

Symbol

BCL2L10

contributors: mct - updated : 27-04-2016

HGNC name	BCL2-like 10 (apoptosis facilitator)
HGNC id	993

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q21.2      Physical location : 52.401.823 - 52.404.972
Synonym name	BCL2-like 10, cell death regulator
Synonym symbol(s)	DIVA, BOO, BCL-B, MGC129810, MGC129811, BCLB

DNA

TYPE	functioning gene
STRUCTURE	3.15 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020396 2 - 887 NP_065129 - 204 - 2003 12921534

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Nervous brain       moderately Reproductive female system ovary       Respiratory lung         Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four BH (Bcl-2 homology) domains (BH1, BH2, BH3 and BH4)
	a predicted C-terminal transmembrane domain

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	ortholog to murine Diva
	homolog to rattus Bcl2l10

Homologene

FAMILY

BCL-2 protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
	intracellular,nuclear envelope
text	translocated to mitochondria in the processing of induced apoptosis

basic FUNCTION	suppressing cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria and thus activating caspase-3 activation when overexpressed
	acting as an apoptosis inhibitor
	promotes cell survival
	novel and prime candidate related to oocyte maturation, fertility, and embryo developmental competence
	anti-apoptotic protein, blocking apoptosis by mitochondrial dependent mechanism
	perform both prosurvival and killing activity

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

reproduction/sex

text	antiapoptotic in glioma cells
	oogenesis
	spermatogenesis

PATHWAY

metabolism

signaling

a component

heterodimerizing with BCL2, BCL2L1/BCL-X(L) and BAX (correlation between binding to pro-apoptotic multidomain Bcl-2 family proteins and functional apoptosis suppression)

INTERACTION

DNA

RNA

small molecule

protein	binding to BAX, BCL2, BCLXL, APAF1
	HIP1R interacts with a member of BCL2 family, BCL2L10, and induces BAK1-dependent cell death
	HRK binds to a specific region in BCL2L10
	UBQLN1 specifically interacts with BCL2L10
	BCL2L10 is a binding partner of TPX2 and a new regulator of the complex controlling the organization of microtubules and microtubule organizing center (MTOC) biogenesis in meiotic spindle assembly
	interaction of UBQLN1 with BCL2L10 is independent of ubiquitination of BCL2L10, but interaction with ubiquitin via UBA domain is required for stabilization of BCL2L10

cell & other

binding to mitochondria and the nuclear envelope

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in gastric carcinoma , and loss of BCL2L10 protein expression predicts poor clinical outcome in gastric carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS