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FLASH GENE
Symbol BCL2L10 contributors: mct - updated : 27-04-2012
HGNC name BCL2-like 10 (apoptosis facilitator)
HGNC id 993
Location 15q21.2      Physical location : 52.401.823 - 52.404.972
Synonym name BCL2-like 10, cell death regulator
Synonym symbol(s) DIVA, BOO, BCL-B, MGC129810, MGC129811
DNA
TYPE functioning gene
STRUCTURE 3.15 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388120 15 hypothetical gene supported by BC013357; NM_016120 ATP8B4 15q15.3 ATPase, Class I, type 8B, member 4 SLC27A2 15q21.2 solute carrier family 27 (fatty acid transporter), member 2 HDC 15q15-q21 histidine decarboxylase GABPB2 15q15.2 GA binding protein transcription factor, beta subunit 2, 47kDa FLJ10038 15q15.3 hypothetical protein FLJ10038 USP8 6p21.3 ubiquitin specific protease 8 TRPM7 15q21 transient receptor potential cation channel, subfamily M, member 7 SPPL2A 15q15.3 putative intramembrane cleaving protease AP4E1 15q15.2 adaptor-related protein complex 4, epsilon 1 subunit LOC388121 15 similar to TNF-induced protein CYP19A1 15q21.1 cytochrome P450, family 19, subfamily A, polypeptide 1 FLJ11181 15q15.3 hypothetical protein FLJ11181 CRG-L2 15q15.3 likely ortholog of mouse cancer related gene - liver 2 RC3 15q15.3 rabconnectin-3 SCG3 15q21 secretogranin III MGC35274 15q21.1 hypothetical protein MGC35274 TMOD2 15q21.1-q21.2 tropomodulin 2 (neuronal) TMOD3 15q21.1-q21.2 tropomodulin 3 (ubiquitous) LOC123169 15q21.1 senescence downregulated leo1-like MAPK6 15q21 mitogen-activated protein kinase 6 BCL2L10 15q21 BCL2-like 10 (apoptosis facilitator) GNB5 15q21 guanine nucleotide binding protein (G protein), beta 5 MYO5C 15q21 myosin VC MYO5A 15q21.1 myosin VA (heavy polypeptide 12, myoxin) EEF1B1 15q15.1-q15.3 eukaryotic translation elongation factor 1 beta 1 ARPP-19 15q15.3 eukaryotic translation elongation factor 1 beta 1 FLJ10980 15q21.1 hypothetical protein FLJ10980 ONECUT1 15q21.1-q21.2 one cut domain, family member 1 LOC388122 15 similar to Laminin receptor 1 LOC390585 15 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC388123 15 LOC388123 FLJ38736 15q21.1 hypothetical protein FLJ38736 UNC13C 15q21.1 unc-13 homolog C (C. elegans)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 887 - 204 - 2003 12921534
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   moderately
Reproductivefemale systemovary   
Respiratorylung    
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticplasma  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four BH (Bcl-2 homology) domains (BH1, BH2, BH3 and BH4)
  • a predicted C-terminal transmembrane domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Diva
    homolog to rattus Bcl2l10
    Homologene
    FAMILY BCL-2 protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    text translocated to mitochondria in the processing of induced apoptosis
    basic FUNCTION
  • suppressing cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria and thus activating caspase-3 activation when overexpressed
  • acting as an apoptosis inhibitor
  • promotes cell survival
  • novel and prime candidate related to oocyte maturation, fertility, and embryo developmental competence
  • anti-apoptotic protein, blocking apoptosis by mitochondrial dependent mechanism
  • perform both prosurvival and killing activity
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • antiapoptotic in glioma cells
  • oogenesis
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with BCL2, BCL2L1/BCL-X(L) and BAX (correlation between binding to pro-apoptotic multidomain Bcl-2 family proteins and functional apoptosis suppression)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to BAX, BCL2, BCLXL, APAF1
  • HIP1R interacts with a member of BCL2 family, BCL2L10, and induces BAK1-dependent cell death
  • HRK binds to a specific region in BCL2L10
  • UBQLN1 specifically interacts with BCL2L10
  • cell & other binding to mitochondria and the nuclear envelope
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric carcinoma , and loss of BCL2L10 protein expression predicts poor clinical outcome in gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS