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FLASH GENE
Symbol BCL2L10 contributors: mct - updated : 27-04-2016
HGNC name BCL2-like 10 (apoptosis facilitator)
HGNC id 993
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four BH (Bcl-2 homology) domains (BH1, BH2, BH3 and BH4)
  • a predicted C-terminal transmembrane domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Diva
    homolog to rattus Bcl2l10
    Homologene
    FAMILY BCL-2 protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    text translocated to mitochondria in the processing of induced apoptosis
    basic FUNCTION
  • suppressing cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria and thus activating caspase-3 activation when overexpressed
  • acting as an apoptosis inhibitor
  • promotes cell survival
  • novel and prime candidate related to oocyte maturation, fertility, and embryo developmental competence
  • anti-apoptotic protein, blocking apoptosis by mitochondrial dependent mechanism
  • perform both prosurvival and killing activity
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS reproduction/sex
    text
  • antiapoptotic in glioma cells
  • oogenesis
  • spermatogenesis
  • PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with BCL2, BCL2L1/BCL-X(L) and BAX (correlation between binding to pro-apoptotic multidomain Bcl-2 family proteins and functional apoptosis suppression)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to BAX, BCL2, BCLXL, APAF1
  • HIP1R interacts with a member of BCL2 family, BCL2L10, and induces BAK1-dependent cell death
  • HRK binds to a specific region in BCL2L10
  • UBQLN1 specifically interacts with BCL2L10
  • BCL2L10 is a binding partner of TPX2 and a new regulator of the complex controlling the organization of microtubules and microtubule organizing center (MTOC) biogenesis in meiotic spindle assembly
  • interaction of UBQLN1 with BCL2L10 is independent of ubiquitination of BCL2L10, but interaction with ubiquitin via UBA domain is required for stabilization of BCL2L10
  • cell & other binding to mitochondria and the nuclear envelope
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric carcinoma , and loss of BCL2L10 protein expression predicts poor clinical outcome in gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS