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FLASH GENE
Symbol BCAR1 contributors: mct - updated : 30-11-2015
HGNC name breast cancer anti-estrogen resistance 1
HGNC id 971
Location 16q23.1      Physical location : 75.262.928 - 75.301.951
Synonym name
  • Crk-associated substrate p130Cas
  • Cas scaffolding protein family member 1
  • Synonym symbol(s) CAS, CRKAS, P130CAS, BCA1, CAS1, CASS1
    DNA
    TYPE functioning gene
    STRUCTURE 39.02 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390740 16 similar to peptidylprolyl isomerase A (cyclophilin A) PSMD7 16q22.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) LOC388291 16 LOC388291 LOC283922 16q22.3 hypothetical protein LOC283922 LOC388292 16 similar to NPIP-like protein LOC388293 16 similar to nuclear pore complex interacting protein LOC388294 16 similar to secretory protein LOC348174 LOC388295 16 LOC388295 GLG1 16q22-q23 golgi apparatus protein 1 FLJ10520 16q22.3 hypothetical protein FLJ10520 FLJ34389 16q22.3 hypothetical protein FLJ34389 FA2H 16q23 fatty acid 2-hydroxylase FLJ12270 16q22.3 hypothetical protein FLJ12270 ZNRF1 16q22.3 zinc and ring finger protein 1 LDHD 16q22.3 lactate dehydrogenase D ZFP1 16q22.3 zinc finger protein 1 homolog (mouse) CTRB1 16q23.1-q23.2 chymotrypsinogen B1 LOC390741 16 similar to 40S ribosomal protein S4, Y isoform LOC339102 16q22.3 similar to Chymotrypsinogen B precursor LOC146599 16q22.3 hypothetical LOC146599 BCAR1 16q22-q23 breast cancer anti-estrogen resistance 1 LOC388296 16 LOC388296 CFDP1 16q22.2-q22.3 craniofacial development protein 1 LOC388297 16 similar to hypothetical protein - fruit fly (Drosophila melanogaster) transposon pogoR11 LOC124491 16q22.3 LOC124491 CHST6 16q22 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 LOC388298 16 LOC388298 CHST5 16q23.1 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 GABARAPL2 16q22.3-q24.1 GABA(A) receptor-associated protein-like 2 ADAT1 16q22.2-q22.3 adenosine deaminase, tRNA-specific 1 KARS 16q23-q24 lysyl-tRNA synthetase TERF2IP 16q22.3 telomeric repeat binding factor 2, interacting protein LOC342409 16q23.1 similar to Hypothetical protein MGC67567 LOC124496 16q23.1 similar to ATP synthase B chain, mitochondrial precursor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3238 93 888 - -
    7 - 3195
    7 - 3281 - 870 - -
    8 - 3533 - 916 - -
    8 - 2943 - 722 - -
    7 - 3257 - 870 - -
    7 - 3311 - 888 - -
    7 - 3372 - 868 - -
    6 - 3470 - 660 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrinethyroid   highly
    Nervousbrain   moderately
     nerve   highly
    Respiratorylung   highly
    Skin/Tegumentskin   moderately
    Urinarybladder   moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SH3 domain followed by multiple YXXP motifs
  • a proline-rich region
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Bcar1 (91.7 pc)
    homolog to murine Bcar1 (91.2 pc)
    Homologene
    FAMILY
  • CAS family
  • CATEGORY adhesion , enzyme , storage
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • ruffle
  • focal adhesion
  • basic FUNCTION
  • playing a central coordinating role for tyrosine-kinase based signaling related to cell-adhesion and induction of cell migration
  • acting as a signal transducer
  • being a key component in the netrin signal transduction pathway
  • playing an important role in guiding commissural axons
  • junction protein that is important to the adhesion between cytoskeleton and extracellular matrix
  • plays important roles in the invasion, metastasis and prognosis of hepatocellular carcinoma
  • role in the regulation of vascular smooth muscle contractility, cell migration, hypertrophy, and growth
  • act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and is linked to a role in progenitor cell function
  • represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells
  • essential transducer in ERBB2 transformation
  • important role for Cas proteins in cell-cell adhesion signaling in development
  • new role for CAS proteins in cell-cell adhesion signaling in cancer
  • major tyrosine-phosphorylated protein in cells transformed by CRK and SRC oncogenes, playing an important role in invasiveness of SRC-transformed cells
  • BCAR1 and EZR are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination
  • in Ovarian cancer, the role of EZR in disease progression is more pronounced than that of BCAR1
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • critical role for a novel NRP1-BCAR1 pathway in the regulation of chemotaxis
  • PTK6-BCAR1-MAPK7 signaling cascade plays an important role in cancer cell migration and invasion
  • a component
  • complexing with PTK2B, CKRL
  • forming complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase
  • can heterodimerize with CASL
  • CAS scaffolding proteins (NEDD9, BCAR1, and CASS4) regulate cell migration, division and survival, and are often deregulated in cancer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NPHP4, PTK2B
  • interacting with BCAR3, NPHP1, PTK2B and SH2D3C
  • interacting with activated CSPG4
  • interacting with INPPL1/SHIP2
  • PTPRS interacting with PPFIA4, BCAR1, TRIO
  • physiological substrate of SYK
  • is a novel direct substrate of PTK6, and it works as a crucial adapter protein in inducing peripheral adhesion complexes
  • N-terminus of BCAR1 associates with the PTK2-WASL complex at the protrusive edge of the cell and the C-terminus of BCAR1 associates with the immobilized integrin-Src family kinases (SFKs) cluster
  • cell & other
    REGULATION
    Other unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpression confers anti-estrogen resistance on breast cancer cells
    tumoral     --over  
    linked to poor prognosis in breast cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential use as a novel therapeutic target in ERBB2 positive human breast cancers
    miscelleaneoushypertension 
    CAS-associated processes may be new biological targets for the development of new treatment of cardiovascular diseases such as hypertension
    ANIMAL & CELL MODELS