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FLASH GENE

Symbol

BCAR1

contributors: mct - updated : 30-11-2015

HGNC name	breast cancer anti-estrogen resistance 1
HGNC id	971

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16q23.1      Physical location : 75.262.928 - 75.301.951
Synonym name	Crk-associated substrate p130Cas
	Cas scaffolding protein family member 1
Synonym symbol(s)	CAS, CRKAS, P130CAS, BCA1, CAS1, CASS1

DNA

TYPE	functioning gene
STRUCTURE	39.02 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001170715 7 - 3238 93 888 - - NM_001170716 7 - 3195 NM_001170718 7 - 3281 - 870 - - NM_001170714 8 - 3533 - 916 - - NM_001170720 8 - 2943 - 722 - - NM_014567 7 - 3257 - 870 - - NM_001170717 7 - 3311 - 888 - - NM_001170719 7 - 3372 - 868 - - NM_001170721 6 - 3470 - 660 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine thyroid       highly Nervous brain       moderately   nerve       highly Respiratory lung       highly Skin/Tegument skin       moderately Urinary bladder       moderately Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one SH3 domain followed by multiple YXXP motifs
	a proline-rich region

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to rattus Bcar1 (91.7 pc)
	homolog to murine Bcar1 (91.2 pc)

Homologene

FAMILY

CAS family

CATEGORY

adhesion , enzyme , storage

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
text	ruffle
	focal adhesion

basic FUNCTION	playing a central coordinating role for tyrosine-kinase based signaling related to cell-adhesion and induction of cell migration
	acting as a signal transducer
	being a key component in the netrin signal transduction pathway
	playing an important role in guiding commissural axons
	junction protein that is important to the adhesion between cytoskeleton and extracellular matrix
	plays important roles in the invasion, metastasis and prognosis of hepatocellular carcinoma
	role in the regulation of vascular smooth muscle contractility, cell migration, hypertrophy, and growth
	act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and is linked to a role in progenitor cell function
	represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells
	essential transducer in ERBB2 transformation
	important role for Cas proteins in cell-cell adhesion signaling in development
	new role for CAS proteins in cell-cell adhesion signaling in cancer
	major tyrosine-phosphorylated protein in cells transformed by CRK and SRC oncogenes, playing an important role in invasiveness of SRC-transformed cells
	BCAR1 and EZR are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination
	in Ovarian cancer, the role of EZR in disease progression is more pronounced than that of BCAR1

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

	critical role for a novel NRP1-BCAR1 pathway in the regulation of chemotaxis
	PTK6-BCAR1-MAPK7 signaling cascade plays an important role in cancer cell migration and invasion

a component	complexing with PTK2B, CKRL
	forming complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase
	can heterodimerize with CASL
	CAS scaffolding proteins (NEDD9, BCAR1, and CASS4) regulate cell migration, division and survival, and are often deregulated in cancer

INTERACTION

DNA

RNA

small molecule

protein	NPHP4, PTK2B
	interacting with BCAR3, NPHP1, PTK2B and SH2D3C
	interacting with activated CSPG4
	interacting with INPPL1/SHIP2
	PTPRS interacting with PPFIA4, BCAR1, TRIO
	physiological substrate of SYK
	is a novel direct substrate of PTK6, and it works as a crucial adapter protein in inducing peripheral adhesion complexes
	N-terminus of BCAR1 associates with the PTK2-WASL complex at the protrusive edge of the cell and the C-terminus of BCAR1 associates with the immobilized integrin-Src family kinases (SFKs) cluster

cell & other

REGULATION

Other

unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpression confers anti-estrogen resistance on breast cancer cells tumoral     --over   linked to poor prognosis in breast cancer patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast potential use as a novel therapeutic target in ERBB2 positive human breast cancers miscelleaneous hypertension   CAS-associated processes may be new biological targets for the development of new treatment of cardiovascular diseases such as hypertension

ANIMAL & CELL MODELS