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Symbol BCAR1 contributors: mct - updated : 30-11-2015
HGNC name breast cancer anti-estrogen resistance 1
HGNC id 971
Location 16q23.1      Physical location : 75.262.928 - 75.301.951
Synonym name
  • Crk-associated substrate p130Cas
  • Cas scaffolding protein family member 1
  • Synonym symbol(s) CAS, CRKAS, P130CAS, BCA1, CAS1, CASS1
    TYPE functioning gene
    STRUCTURE 39.02 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390740 16 similar to peptidylprolyl isomerase A (cyclophilin A) PSMD7 16q22.2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog) LOC388291 16 LOC388291 LOC283922 16q22.3 hypothetical protein LOC283922 LOC388292 16 similar to NPIP-like protein LOC388293 16 similar to nuclear pore complex interacting protein LOC388294 16 similar to secretory protein LOC348174 LOC388295 16 LOC388295 GLG1 16q22-q23 golgi apparatus protein 1 FLJ10520 16q22.3 hypothetical protein FLJ10520 FLJ34389 16q22.3 hypothetical protein FLJ34389 FA2H 16q23 fatty acid 2-hydroxylase FLJ12270 16q22.3 hypothetical protein FLJ12270 ZNRF1 16q22.3 zinc and ring finger protein 1 LDHD 16q22.3 lactate dehydrogenase D ZFP1 16q22.3 zinc finger protein 1 homolog (mouse) CTRB1 16q23.1-q23.2 chymotrypsinogen B1 LOC390741 16 similar to 40S ribosomal protein S4, Y isoform LOC339102 16q22.3 similar to Chymotrypsinogen B precursor LOC146599 16q22.3 hypothetical LOC146599 BCAR1 16q22-q23 breast cancer anti-estrogen resistance 1 LOC388296 16 LOC388296 CFDP1 16q22.2-q22.3 craniofacial development protein 1 LOC388297 16 similar to hypothetical protein - fruit fly (Drosophila melanogaster) transposon pogoR11 LOC124491 16q22.3 LOC124491 CHST6 16q22 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 LOC388298 16 LOC388298 CHST5 16q23.1 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 GABARAPL2 16q22.3-q24.1 GABA(A) receptor-associated protein-like 2 ADAT1 16q22.2-q22.3 adenosine deaminase, tRNA-specific 1 KARS 16q23-q24 lysyl-tRNA synthetase TERF2IP 16q22.3 telomeric repeat binding factor 2, interacting protein LOC342409 16q23.1 similar to Hypothetical protein MGC67567 LOC124496 16q23.1 similar to ATP synthase B chain, mitochondrial precursor
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3238 93 888 - -
    7 - 3195
    7 - 3281 - 870 - -
    8 - 3533 - 916 - -
    8 - 2943 - 722 - -
    7 - 3257 - 870 - -
    7 - 3311 - 888 - -
    7 - 3372 - 868 - -
    6 - 3470 - 660 - -
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Endocrinethyroid   highly
    Nervousbrain   moderately
     nerve   highly
    Respiratorylung   highly
    Skin/Tegumentskin   moderately
    Urinarybladder   moderately
    Visualeye   highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    SystemCellPubmedSpeciesStageRna symbol
    cell lineage
    cell lines
    at STAGE
  • one SH3 domain followed by multiple YXXP motifs
  • a proline-rich region
  • conjugated PhosphoP
    interspecies homolog to rattus Bcar1 (91.7 pc)
    homolog to murine Bcar1 (91.2 pc)
  • CAS family
  • CATEGORY adhesion , enzyme , storage
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
  • ruffle
  • focal adhesion
  • basic FUNCTION
  • playing a central coordinating role for tyrosine-kinase based signaling related to cell-adhesion and induction of cell migration
  • acting as a signal transducer
  • being a key component in the netrin signal transduction pathway
  • playing an important role in guiding commissural axons
  • junction protein that is important to the adhesion between cytoskeleton and extracellular matrix
  • plays important roles in the invasion, metastasis and prognosis of hepatocellular carcinoma
  • role in the regulation of vascular smooth muscle contractility, cell migration, hypertrophy, and growth
  • act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and is linked to a role in progenitor cell function
  • represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells
  • essential transducer in ERBB2 transformation
  • important role for Cas proteins in cell-cell adhesion signaling in development
  • new role for CAS proteins in cell-cell adhesion signaling in cancer
  • major tyrosine-phosphorylated protein in cells transformed by CRK and SRC oncogenes, playing an important role in invasiveness of SRC-transformed cells
  • BCAR1 and EZR are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination
  • in Ovarian cancer, the role of EZR in disease progression is more pronounced than that of BCAR1
  • CELLULAR PROCESS cell life, proliferation/growth
    signaling signal transduction
  • critical role for a novel NRP1-BCAR1 pathway in the regulation of chemotaxis
  • PTK6-BCAR1-MAPK7 signaling cascade plays an important role in cancer cell migration and invasion
  • a component
  • complexing with PTK2B, CKRL
  • forming complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase
  • can heterodimerize with CASL
  • CAS scaffolding proteins (NEDD9, BCAR1, and CASS4) regulate cell migration, division and survival, and are often deregulated in cancer
    small molecule
  • NPHP4, PTK2B
  • interacting with BCAR3, NPHP1, PTK2B and SH2D3C
  • interacting with activated CSPG4
  • interacting with INPPL1/SHIP2
  • PTPRS interacting with PPFIA4, BCAR1, TRIO
  • physiological substrate of SYK
  • is a novel direct substrate of PTK6, and it works as a crucial adapter protein in inducing peripheral adhesion complexes
  • N-terminus of BCAR1 associates with the PTK2-WASL complex at the protrusive edge of the cell and the C-terminus of BCAR1 associates with the immobilized integrin-Src family kinases (SFKs) cluster
  • cell & other
    Other unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpression confers anti-estrogen resistance on breast cancer cells
    tumoral     --over  
    linked to poor prognosis in breast cancer patients
    Variant & Polymorphism
    Candidate gene
    Therapy target
    potential use as a novel therapeutic target in ERBB2 positive human breast cancers
    CAS-associated processes may be new biological targets for the development of new treatment of cardiovascular diseases such as hypertension