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FLASH GENE
Symbol BCAR1 contributors: mct - updated : 30-11-2015
HGNC name breast cancer anti-estrogen resistance 1
HGNC id 971
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SH3 domain followed by multiple YXXP motifs
  • a proline-rich region
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Bcar1 (91.7 pc)
    homolog to murine Bcar1 (91.2 pc)
    Homologene
    FAMILY
  • CAS family
  • CATEGORY adhesion , enzyme , storage
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • ruffle
  • focal adhesion
  • basic FUNCTION
  • playing a central coordinating role for tyrosine-kinase based signaling related to cell-adhesion and induction of cell migration
  • acting as a signal transducer
  • being a key component in the netrin signal transduction pathway
  • playing an important role in guiding commissural axons
  • junction protein that is important to the adhesion between cytoskeleton and extracellular matrix
  • plays important roles in the invasion, metastasis and prognosis of hepatocellular carcinoma
  • role in the regulation of vascular smooth muscle contractility, cell migration, hypertrophy, and growth
  • act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and is linked to a role in progenitor cell function
  • represents a nodal scaffold protein regulating cell survival, migration, and proliferation in normal and pathological cells
  • essential transducer in ERBB2 transformation
  • important role for Cas proteins in cell-cell adhesion signaling in development
  • new role for CAS proteins in cell-cell adhesion signaling in cancer
  • major tyrosine-phosphorylated protein in cells transformed by CRK and SRC oncogenes, playing an important role in invasiveness of SRC-transformed cells
  • BCAR1 and EZR are structural proteins with an important role in signaling pathways and have been shown to promote cancer dissemination
  • in Ovarian cancer, the role of EZR in disease progression is more pronounced than that of BCAR1
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • critical role for a novel NRP1-BCAR1 pathway in the regulation of chemotaxis
  • PTK6-BCAR1-MAPK7 signaling cascade plays an important role in cancer cell migration and invasion
  • a component
  • complexing with PTK2B, CKRL
  • forming complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase
  • can heterodimerize with CASL
  • CAS scaffolding proteins (NEDD9, BCAR1, and CASS4) regulate cell migration, division and survival, and are often deregulated in cancer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NPHP4, PTK2B
  • interacting with BCAR3, NPHP1, PTK2B and SH2D3C
  • interacting with activated CSPG4
  • interacting with INPPL1/SHIP2
  • PTPRS interacting with PPFIA4, BCAR1, TRIO
  • physiological substrate of SYK
  • is a novel direct substrate of PTK6, and it works as a crucial adapter protein in inducing peripheral adhesion complexes
  • N-terminus of BCAR1 associates with the PTK2-WASL complex at the protrusive edge of the cell and the C-terminus of BCAR1 associates with the immobilized integrin-Src family kinases (SFKs) cluster
  • cell & other
    REGULATION
    Other unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpression confers anti-estrogen resistance on breast cancer cells
    tumoral     --over  
    linked to poor prognosis in breast cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential use as a novel therapeutic target in ERBB2 positive human breast cancers
    miscelleaneoushypertension 
    CAS-associated processes may be new biological targets for the development of new treatment of cardiovascular diseases such as hypertension
    ANIMAL & CELL MODELS